Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Sci Rep. 2017 Aug 29;7(1):9636. doi: 10.1038/s41598-017-09719-8.
Serum gamma-glutamyltransferase (γ-GT) is implicated in the pathogenesis of atherosclerosis and metabolic syndrome (MetS) in adults. The relationships between γ-GT and cardiometabolic dysregulation remains unclear in adolescents. We enrolled 7,072 Taiwanese adolescents and followed them for a median of 6.8 years. The optimal cut-off values (CoVs) of baseline γ-GT to predict future MetS, hypertension (HTN), and type 2 diabetes (T2DM) were determined by receiving operating characteristic (ROC) curve. Using these CoVs, the participants were divided into normal- and high-level groups. Cox proportional hazard analysis was used to calculate hazard ratios (HRs) for the subjects with a high level of γ-GT for the risk of future cardiometabolic dysregulation. Serum γ-GT was significantly higher in the subjects with MetS than in those without MetS at baseline (p < 0.001). The optimal CoVs of γ-GT were 12 U/L for boys and 11 U/L for girls. In multivariate Cox regression analysis, a higher serum γ-GT level increased the risk of future MetS (HRs 1.98 and 2.85 for boys and girls, respectively, both p < 0.001), but not new onset HTN and T2DM. In conclusion, serum γ-GT levels not only demonstrated an excellent correlation with the presence of MetS and also in predicting future MetS in adolescents.
血清γ-谷氨酰转移酶（γ-GT）与成人动脉粥样硬化和代谢综合征（MetS）的发病机制有关。γ-GT 与心脏代谢失调之间的关系在青少年中仍不清楚。我们招募了 7072 名台湾青少年，并对他们进行了中位数为 6.8 年的随访。通过接受操作特征（ROC）曲线，确定了基线γ-GT 预测未来 MetS、高血压（HTN）和 2 型糖尿病（T2DM）的最佳截断值（CoV）。使用这些 CoV，将参与者分为正常和高水平组。Cox 比例风险分析用于计算高水平γ-GT 受试者未来发生心脏代谢失调的风险比（HR）。在基线时，患有 MetS 的受试者的血清γ-GT 明显高于没有 MetS 的受试者（p<0.001）。γ-GT 的最佳 CoV 为男孩 12 U/L，女孩 11 U/L。在多变量 Cox 回归分析中，较高的血清γ-GT 水平增加了未来 MetS 的风险（男孩和女孩的 HR 分别为 1.98 和 2.85，均 p<0.001），但不会增加新发生的 HTN 和 T2DM 的风险。总之，血清γ-GT 水平不仅与 MetS 的存在密切相关，而且可以预测青少年未来的 MetS。
