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RNA. 2007 Sep;13(9):1397-401. doi: 10.1261/rna.659307. Epub 2007 Jul 24.
2
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本文引用的文献

1
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends.Pimet是HEN1在果蝇中的同源物，介导与Piwi相互作用的RNA在其3'端的2'-O-甲基化。
Genes Dev. 2007 Jul 1;21(13):1603-8. doi: 10.1101/gad.1563607.
2
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.果蝇RNA甲基转移酶DmHen1可修饰生殖系piRNA和RISC中的单链siRNA。
Curr Biol. 2007 Jul 17;17(14):1265-72. doi: 10.1016/j.cub.2007.06.030. Epub 2007 Jun 28.
3
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.Piwi蛋白和piRNA在斑马鱼生殖细胞维持及转座子沉默中的作用
Cell. 2007 Apr 6;129(1):69-82. doi: 10.1016/j.cell.2007.03.026.
4
Mighty Piwis defend the germline against genome intruders.强大的Piwi蛋白保护生殖系免受基因组入侵者的侵害。
Cell. 2007 Apr 6;129(1):37-44. doi: 10.1016/j.cell.2007.03.028.
5
Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.小鼠Piwi相互作用RNA在其3'末端被2'-O-甲基化。
Nat Struct Mol Biol. 2007 Apr;14(4):347-8. doi: 10.1038/nsmb1218. Epub 2007 Mar 25.
6
The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated.小鼠Piwi相互作用RNA的3'末端发生了2'-O-甲基化修饰。
Nat Struct Mol Biol. 2007 Apr;14(4):349-50. doi: 10.1038/nsmb1220. Epub 2007 Mar 25.
7
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.作为果蝇转座子活性主要调控因子的离散小RNA生成位点
Cell. 2007 Mar 23;128(6):1089-103. doi: 10.1016/j.cell.2007.01.043. Epub 2007 Mar 8.
8
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.果蝇中一种由切片酶介导的与重复序列相关的小干扰RNA 5'端形成机制。
Science. 2007 Mar 16;315(5818):1587-90. doi: 10.1126/science.1140494. Epub 2007 Feb 22.
9
Repression of protein synthesis by miRNAs: how many mechanisms?微小RNA对蛋白质合成的抑制作用：有多少种机制？
Trends Cell Biol. 2007 Mar;17(3):118-26. doi: 10.1016/j.tcb.2006.12.007. Epub 2007 Jan 2.
10
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans.大规模测序揭示了秀丽隐杆线虫中的21U-RNA以及其他微小RNA和内源性小干扰RNA。
Cell. 2006 Dec 15;127(6):1193-207. doi: 10.1016/j.cell.2006.10.040.

HEN1的小鼠同源物是一种潜在的与Piwi相互作用RNA的甲基化酶。

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs.

作者信息

Kirino Yohei, Mourelatos Zissimos

出版信息

RNA. 2007 Sep;13(9):1397-401. doi: 10.1261/rna.659307. Epub 2007 Jul 24.

DOI:10.1261/rna.659307
PMID:17652135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1950760/
Abstract

Piwi-interacting RNAs (piRNAs) are a novel class of small regulatory RNAs that are expressed specifically and abundantly in germ cells. Mammalian piRNAs are 26-31 nucleotides in length and bind to Piwi proteins, but their function and biogenesis remain elusive. We previously showed that mammalian piRNAs are 2'-O-methylated at their 3' termini. The biosynthetic mechanism and function of this modification is unknown. Here, we report that the mouse homolog (mHEN1) of HEN1, a plant microRNA (miRNA) 2'-O-methyltransferase, is expressed specifically in testis and methylates 3' termini of piRNAs in vitro. These findings provide insight into the biogenesis of piRNAs.

摘要

Piwi相互作用RNA（piRNA）是一类新型的小调节RNA，在生殖细胞中特异性且大量表达。哺乳动物的piRNA长度为26 - 31个核苷酸，并与Piwi蛋白结合，但其功能和生物合成机制仍不清楚。我们之前表明，哺乳动物的piRNA在其3'末端发生2'-O-甲基化。这种修饰的生物合成机制和功能尚不清楚。在这里，我们报道植物微小RNA（miRNA）2'-O-甲基转移酶HEN1的小鼠同源物（mHEN1）在睾丸中特异性表达，并在体外使piRNA的3'末端甲基化。这些发现为piRNA的生物合成提供了见解。