Swift Luther, McHowat Jane, Sarvazyan Narine
Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA.
Cardiovasc Toxicol. 2007;7(2):86-91. doi: 10.1007/s12012-007-0012-6.
The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of the early culprits leading to anthracycline-induced cardiac dysfunction. The clinical importance and potential pharmaceutical use of this new phenomenon await further studies.
本文的目的是概述我们的研究结果,即低浓度、临床相关浓度的蒽环类药物可显著抑制膜相关钙非依赖性磷脂酶A2。我们的研究表明,由于该酶在膜稳态中起关键作用,其抑制作用可能是导致蒽环类药物引起心脏功能障碍的早期罪魁祸首之一。这一新现象的临床重要性和潜在药物用途有待进一步研究。