Ruiz J R, Ortega F B, Warnberg J, Sjöström M
Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, 14157 Huddinge, Sweden.
Int J Obes (Lond). 2007 Oct;31(10):1545-51. doi: 10.1038/sj.ijo.0803693. Epub 2007 Jul 24.
To examine the associations of low-grade inflammation with objectively measured physical activity, cardiovascular fitness (CVF) and fatness in prepubertal children.
Cross-sectional study.
One hundred and forty-two children (74 boys and 68 girls) aged 9-10 years (pubertal stage I and II) from the Swedish part of the European Youth Heart Study.
Total physical activity and its intensity levels (moderate, vigorous, moderate + vigorous) were measured by accelerometry. CVF was measured with a maximal ergometer bike test. Body fat was derived from the sum of five skinfold thicknesses. The measured low-grade inflammatory markers include C-reactive protein, fibrinogen, complement factors C3 and C4.
C-reactive protein and C3 were negatively associated with CVF (beta=-0.254 and -0.267, respectively, P<0.05) and positively associated with body fat (beta=0.439 and 0.446, respectively, P<0.001), after controlling for sex, age and pubertal development. C-reactive protein and C3 were not significantly associated with CVF once body fat was in the model. Low-grade inflammation was not associated with physical activity, but physical activity was associated with CVF.
The results showed that low-grade inflammatory markers were negatively associated with CVF and positively associated with body fat in prepubertal children. For most of the variables, the influence of fatness was slightly higher than the influence of CVF. The findings suggest that the potential beneficial effects of physical activity on low-grade inflammation may be explained by its association with CVF. Understanding the interplay between physical activity, CVF and fatness may be of importance to reducing cardiovascular disease risk in young people.
研究青春期前儿童低度炎症与客观测量的身体活动、心血管健康状况（CVF）及肥胖之间的关联。
横断面研究。
来自欧洲青年心脏研究瑞典部分的142名9至10岁（青春期I期和II期）儿童（74名男孩和68名女孩）。
通过加速度计测量总身体活动及其强度水平（中度、剧烈、中度+剧烈）。通过最大运动功率自行车测试测量CVF。体脂由五个皮褶厚度之和得出。所测量的低度炎症标志物包括C反应蛋白、纤维蛋白原、补体因子C3和C4。
在控制性别、年龄和青春期发育后，C反应蛋白和C3与CVF呈负相关（β分别为-0.254和-0.267，P<0.05），与体脂呈正相关（β分别为0.439和0.446，P<0.001）。一旦模型中纳入体脂，C反应蛋白和C3与CVF无显著关联。低度炎症与身体活动无关，但身体活动与CVF有关。
结果表明，青春期前儿童低度炎症标志物与CVF呈负相关，与体脂呈正相关。对于大多数变量，肥胖的影响略高于CVF的影响。研究结果表明，身体活动对低度炎症的潜在有益作用可能通过其与CVF的关联来解释。了解身体活动、CVF和肥胖之间的相互作用对于降低年轻人心血管疾病风险可能具有重要意义。
