Brook I
Naval Medical Center, Bethesda, Md.
Gynecol Obstet Invest. 1991;32(1):44-50. doi: 10.1159/000292991.
Pelvic inflammatory disease (PID) is a polymicrobial infection that evolves multiple aerobic and anaerobic bacteria. Several of the bacterial pathogens that participate in PID can produce the enzyme beta lactamase. These include Bacteroides species (including Bacteroides bivius, Bacteroides disiens, and Bacteroides fragilis group), Neisseria gonorrheae, Enterobacteriaceae and Staphylococcus aureus. A recent increase in numbers of beta-lactamase-producing strains of these organisms in PID has been associated with increased failure rates of penicillins in eradication of this infection. These organisms cannot only survive penicillin therapy but also protect penicillin-susceptible pathogens from the drug. These direct and indirect virulence characteristics of beta-lactamase-producing bacteria require the administration of appropriate antimicrobial therapy directed against all of these pathogens in the therapy of PID.
盆腔炎（PID）是一种由多种需氧菌和厌氧菌引起的混合感染。参与PID的几种细菌病原体可产生β-内酰胺酶。这些病原体包括拟杆菌属（包括二路拟杆菌、差异拟杆菌和脆弱拟杆菌群）、淋病奈瑟菌、肠杆菌科细菌和金黄色葡萄球菌。近年来，PID中这些产生β-内酰胺酶菌株的数量增加，与青霉素根除这种感染的失败率上升有关。这些病原体不仅能在青霉素治疗中存活，还能保护对青霉素敏感的病原体免受药物影响。产生β-内酰胺酶细菌的这些直接和间接毒力特性要求在PID治疗中使用针对所有这些病原体的适当抗菌疗法。
