Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.
BMC Infect Dis. 2009 Dec 14;9:202. doi: 10.1186/1471-2334-9-202.
Beta-lactamase-producing bacteria (BLPB) can play an important role in polymicrobial infections. They can have a direct pathogenic impact in causing the infection as well as an indirect effect through their ability to produce the enzyme beta-lactamase. BLPB may not only survive penicillin therapy but can also, as was demonstrated in in vitro and in vivo studies, protect other penicillin-susceptible bacteria from penicillin by releasing the free enzyme into their environment. This phenomenon occurs in upper respiratory tract, skin, soft tissue, surgical and other infections. The clinical, in vitro, and in vivo evidence supporting the role of these organisms in the increased failure rate of penicillin in eradication of these infections and the implication of that increased rate on the management of infections is discussed.
产β-内酰胺酶细菌（BLPB）在混合感染中可发挥重要作用。它们不仅可通过产生β-内酰胺酶而发挥直接的致病作用，还可通过这种能力间接影响感染。BLPB 不仅可在青霉素治疗中存活，而且正如体外和体内研究所证实的那样，还可通过将游离酶释放到环境中而保护其他对青霉素敏感的细菌免受青霉素的侵害。这种现象发生在上呼吸道、皮肤、软组织、手术和其他感染中。本文讨论了临床、体外和体内证据支持这些生物体在增加青霉素清除这些感染的失败率方面的作用，以及这种增加的发生率对感染管理的影响。
