Zhang Chun-ze, Tian Zhi-xin, Shi Shuan-zhu, Li Ming-hui, Xie Yao
Department of Infectious Diseases, Hospital of Infectious Disease, Zhangjiakou City, Hebei Province, 075000, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Jun;21(2):138-40.
To investigate the clinical characteristics of anti-HBc IgM positive chronic hepatitis B patients and the relation of anti-HBc IgM development to serum HBV DNA load and the state of HBeAg/anti-HBe.
The clinical data were collected from patients with chronic hepatitis B hospitalized in the Infectious Diseases Hospital, Zhangjiakou city, and in Ditan Hospital, some of whom were anti-HBc IgM positive and some others were negative. Their HBV DNA load was examined by real-time PCR, and HBeAg/anti-HBe was detected by AXSYM auto-enzyme analyzer with the third generation EIA regent.
Totally 200 patients were enrolled in this study. The number of patients with mild, moderate and severe hepatitis was 71, 83 and 46. The anti-HBc IgM positive patients were older and had longer course of disease than those of anti-HBc IgM negative patients. Of the anti-HBc IgM positive group, 45.71 percent and 54.29 percent had mild and moderate hepatitis, which were significantly different from those in the anti-HBc IgM negative patients (30.00 percent and 70.00 percent). But there was no difference between anti-HBc IgM positive and negative patients in serum HBV DNA level, the state of HBeAg/anti-HBe and outcome.
The anti-HBc IgM state of chronic hepatitis B patients was related to the severity of hepatitis, but not with virus load and state of HBeAg/anti-HBe.
探讨抗-HBc IgM阳性慢性乙型肝炎患者的临床特征以及抗-HBc IgM变化与血清HBV DNA载量和HBeAg/抗-HBe状态的关系。
收集张家口市传染病医院和地坛医院住院的慢性乙型肝炎患者的临床资料，其中部分患者抗-HBc IgM阳性，部分患者抗-HBc IgM阴性。采用实时荧光定量PCR检测其HBV DNA载量，用AXSYM全自动酶免疫分析仪及第三代酶免疫试剂检测HBeAg/抗-HBe。
本研究共纳入200例患者。轻度、中度和重度肝炎患者分别为71例、83例和46例。抗-HBc IgM阳性患者比抗-HBc IgM阴性患者年龄大、病程长。抗-HBc IgM阳性组中，轻度和中度肝炎患者分别占45.71%和54.29%，与抗-HBc IgM阴性患者（分别为30.00%和70.00%）有显著差异。但抗-HBc IgM阳性和阴性患者在血清HBV DNA水平、HBeAg/抗-HBe状态及转归方面无差异。
慢性乙型肝炎患者的抗-HBc IgM状态与肝炎严重程度有关，但与病毒载量及HBeAg/抗-HBe状态无关。
