O'Connor Patrick D, Brimble Margaret A
Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Nat Prod Rep. 2007 Aug;24(4):869-85. doi: 10.1039/b700307m. Epub 2007 Apr 2.
An overview of the structure and biological activity of macrocyclic polyketides derived from dinoflagellates that contain unusual cyclic imine units is provided. The total and partial syntheses of these molecules are discussed with an emphasis on the construction of the spiroimine functionality thought to be the key pharmacophore of these fact-acting shellfish toxins.
本文提供了对源自含有不寻常环状亚胺单元的甲藻的大环聚酮化合物的结构和生物活性的概述。讨论了这些分子的全合成和部分合成，重点是对被认为是这些实际作用的贝类毒素关键药效基团的螺亚胺官能团的构建。
