Unal Ekrem, Koksal Yavuz, Vajtai Istvan, Toy Hatice, Kocaogullar Yalcin, Paksoy Yahya
Department of Pediatrics, Meram Faculty of Medicine, Selcuk University, 42080, Meram, Konya, Turkey.
Childs Nerv Syst. 2008 Feb;24(2):165-8. doi: 10.1007/s00381-007-0424-4. Epub 2007 Jul 26.
Astroblastoma, an uncommon neuroepithelial tumor, typically presents in young adults as a well-circumscribed cortical or subcortical spherical mass. Astroblastoma may cause a diagnostic problem to anyone unfamiliar with its architectural and histological features.
We report the case of a 4-year-old boy who was referred for complaints of progressive deficits of balance and difficulty with walking during the previous 3 months. A large fronto-parietal cystic mass with solid mural nodule was discovered. Total removal of the tumor mass was performed, and a diagnosis of high grade (malignant) variant of astroblastoma was made. Postoperatively, the patient received radiation therapy, for a period of 11 weeks, followed by chemotherapy. He is in a good neurological recovery without any evidence of recurrence for 8 months.
The best treatment modality for astroblastoma is surgical resection if possible, whereas adjuvant therapy (radiotherapy and/or chemotherapy) can be considered in high-grade astroblastomas, with a close follow-up for all cases.
成星形细胞瘤是一种罕见的神经上皮肿瘤，通常在年轻人中表现为边界清晰的皮质或皮质下球形肿块。成星形细胞瘤可能会给任何不熟悉其结构和组织学特征的人带来诊断难题。
我们报告一例4岁男孩的病例，该男孩因在前3个月出现进行性平衡障碍和行走困难而前来就诊。发现一个伴有实性壁结节的额顶叶大囊性肿块。对肿瘤肿块进行了全切，诊断为成星形细胞瘤的高级别（恶性）变异型。术后，患者接受了为期11周的放射治疗，随后进行化疗。8个月来，他神经功能恢复良好，无任何复发迹象。
成星形细胞瘤的最佳治疗方式是尽可能进行手术切除，而对于高级别成星形细胞瘤可考虑辅助治疗（放疗和/或化疗），所有病例均需密切随访。
