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一名年轻成人的高级别脑室内成星形细胞瘤:一种罕见且治疗存在争议的肿瘤

High-Grade Intraventricular Astroblastoma in a Young Adult: A Rare and Controversial Tumor to Manage.

作者信息

Singh Karuna, Garg Shipra, Rani Shilp, Sandhu Parvinder

机构信息

Department of Radiation oncology, Advanced Cancer Institute, Bathinda, Punjab, India.

Department of Radiation Oncology, Guru Gobind Singh Medical College, Faridkot, Punjab, India.

出版信息

Asian J Neurosurg. 2021 Sep 14;16(3):567-574. doi: 10.4103/ajns.AJNS_430_20. eCollection 2021 Jul-Sep.

Abstract

Astroblastoma is a rare primary central nervous system tumor of controversial site of origin. They account for 0.45-2.8% of all primary neuroepithelial central nervous system. It has been reported in paediatric age group with bimodal age distribution affecting more females with male to female ratio being 1:11. Astroblastomas are controversial and challenging tumors in terms of diagnosis and therapeutics. Since it carries an unpredictable disease course it needs a regular follow up even for low grade tumor. Authors have tried various schedules of post op radiotherapy after maximum safe resection. Various chemotherapeutic drugs combination have also been tried without much success. We here report a 35 years old female patient who was diagnosed with high grade astroblastoma referred for post-operative radiotherapy after gross total resection. Since it is extremely rare tumor, its treatment still not well defined and also makes it difficult conduct studies to examine tumor characteristics.

摘要

成星形细胞瘤是一种起源部位存在争议的罕见原发性中枢神经系统肿瘤。它们占所有原发性神经上皮性中枢神经系统肿瘤的0.45%-2.8%。已报道其在儿童年龄组中具有双峰年龄分布,女性受影响更多,男女比例为1:11。成星形细胞瘤在诊断和治疗方面是存在争议且具有挑战性的肿瘤。由于其病程不可预测,即使是低级别肿瘤也需要定期随访。作者在最大安全切除术后尝试了各种术后放疗方案。也尝试了各种化疗药物组合,但效果不佳。我们在此报告一名35岁女性患者,她被诊断为高级别成星形细胞瘤,在全切术后转诊接受术后放疗。由于它是极其罕见的肿瘤,其治疗仍未明确界定,这也使得开展研究以检查肿瘤特征变得困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a17d/8477834/d5b8e8d10a8c/AJNS-16-567-g001.jpg

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