Ferrara M, Capozzi L, Coppola A, Save G, Coppola L
Department of Pediatrics, The 2nd University of Naples, Naples, Italy.
Hematology. 2007 Aug;12(4):297-9. doi: 10.1080/10245330701255213.
The safety of low platelet thresholds for prophylactic transfusions was retrospectively evaluated in 673 children with various thrombocytopenic disorders. In patients with idiopathic thrombocytopenic purpura and X linked thrombocytopenia the threshold for the use of platelet transfusion was based on bleeding events rather than platelet count. In children with hypoproliferative thrombocytopenia and Wiskott-Aldrich syndrome, prophylactic platelet transfusions were used when the platelet count was <or= 5000/microl in stable patients and > 10,000/microl in cases of bleeding or infections. The restrictive policy of platelet transfusions was shown to be proved safe in many thrombocytopenic disorders.
对673名患有各种血小板减少性疾病的儿童进行回顾性评估，以探讨预防性输血时低血小板阈值的安全性。对于特发性血小板减少性紫癜和X连锁血小板减少症患者，血小板输注的阈值基于出血事件而非血小板计数。对于增生低下性血小板减少症和Wiskott-Aldrich综合征患儿，稳定患者血小板计数≤5000/微升，出血或感染患者血小板计数>10,000/微升时，采用预防性血小板输注。在许多血小板减少性疾病中，血小板输注的限制性策略已被证明是安全的。
