Jawaid Amna
Department of Paediatrics, Aga Khan University Hospital, Karachi.
J Pak Med Assoc. 2015 Apr;65(4):347-59.
To identify the haematological causes of thrombocytopenia in children admitted at a tertiary care hospital.
The prospective, descriptive study was carried out at the Aga Khan University Hospital, Karachi, from September 3, 2009 to March 3, 2010, and comprised children between one month and 14 years of age with platelet count less than15000. After reviewing the record, a questionnaire was filled and data was analysed using SPSS 15.
Out of 108 patients in the study, 69(64%) were male and 39(36%) were female. The overall mean age was 69±46.54 months (range: 12-168 months). The mean platelet count was 59.8±46.1/µl (range: 1,000-149,000/µl). Besides, 24 (22.2%) children had mild thrombocytopenia, 34(31.5%) had moderate and 50(46.3 %) had severe thrombocytopenia. The causes of haematological thrombocytopenia in descending order of frequency was acute lymphoblastic leukaemia 17(15.7%), idiopathic thrombocytopenic purpura 10(8.3%) and aplastic anaemia 5(4.6%).
Acute lymphoblastic leukaemia was the commonest cause of haematological thrombocytopenia followed by idiopathic thrombocytopenic purpura and aplastic anaemia.
确定在一家三级护理医院住院的儿童血小板减少症的血液学病因。
这项前瞻性描述性研究于2009年9月3日至2010年3月3日在卡拉奇的阿迦汗大学医院开展，纳入年龄在1个月至14岁之间、血小板计数低于15000的儿童。查阅记录后，填写一份问卷，并使用SPSS 15对数据进行分析。
该研究中的108例患者中，69例（64%）为男性，39例（36%）为女性。总体平均年龄为69±46.54个月（范围：12 - 168个月）。平均血小板计数为59.8±46.1/µl（范围：1000 - 149000/µl）。此外，24例（22.2%）儿童有轻度血小板减少症，34例（31.5%）有中度血小板减少症，50例（46.3%）有重度血小板减少症。血液学血小板减少症的病因按发生频率从高到低依次为急性淋巴细胞白血病17例（15.7%）、特发性血小板减少性紫癜10例（8.3%）和再生障碍性贫血5例（4.6%）。
急性淋巴细胞白血病是血液学血小板减少症最常见的病因，其次是特发性血小板减少性紫癜和再生障碍性贫血。
