Morris T W, Ekholm S E, Prentice L I
Department of Radiology, University of Rochester Medical Center, New York 14642.
Invest Radiol. 1991 Dec;26(12):1087-90. doi: 10.1097/00004424-199112000-00011.
Gadolinium DTPA and DOTA are being used extensively for imaging blood-brain barrier lesions. This study was performed to determine clinically relevant blood, cerebrospinal fluid (CSF), and neural tissue concentrations of these agents, and to determine if they alter neural tissue glucose metabolism. Bolus injections of 0.2 mmol Gd-DTPA/kg were made in rabbits, and blood, CSF, and neural tissue Gd concentrations were measured using atomic emission. Rat hippocampus slices were incubated for 6 hours in solutions of Gd-DTPA and Gd-DOTA, and effects on the production of carbon-14-labeled CO2 from glucose determined. Plasma concentrations reached a peak of 2.46 mmol at 1 minute postinjection, and dropped to 50% of peak in 6 minutes. The highest CSF concentration observed was approximately 0.1 mmol, and the mean lumbar cord concentration was approximately 8.5 mumol/g. Gd-DTPA and Gd-DOTA concentrations greater than 1.0 mmol caused significant increases in CO2 production. In areas of blood-brain barrier lesions, Gd-DTPA and Gd-DOTA may cause changes in tissue metabolism; however, in other areas it is much less likely.
钆喷酸葡胺（Gadolinium DTPA）和钆喷酸四氮杂环十二烷四乙酸（DOTA）被广泛用于血脑屏障病变的成像。本研究旨在确定这些药物在血液、脑脊液（CSF）和神经组织中的临床相关浓度，并确定它们是否会改变神经组织的葡萄糖代谢。给兔子静脉推注0.2 mmol钆喷酸葡胺/千克，使用原子发射法测量血液、脑脊液和神经组织中的钆浓度。将大鼠海马切片在钆喷酸葡胺和钆喷酸四氮杂环十二烷四乙酸溶液中孵育6小时，测定其对葡萄糖产生碳-14标记二氧化碳的影响。注射后1分钟血浆浓度达到峰值2.46 mmol，并在6分钟内降至峰值的50%。观察到的最高脑脊液浓度约为0.1 mmol，平均腰髓浓度约为8.5 μmol/g。钆喷酸葡胺和钆喷酸四氮杂环十二烷四乙酸浓度大于1.0 mmol会导致二氧化碳产生显著增加。在血脑屏障病变区域，钆喷酸葡胺和钆喷酸四氮杂环十二烷四乙酸可能会引起组织代谢变化；然而，在其他区域这种可能性要小得多。
