Corot C, Belleville J, Paul J, Baguet J, Amiel M, Eloy R
INSERM U.37, Bron, France.
Invest Radiol. 1988 Sep;23 Suppl 1:S261-3. doi: 10.1097/00004424-198809001-00056.
The interactions of two gadolinium complexes (Gd-DOTA meglumine and Gd-DTPA meglumine) with hemostatic function have been analyzed using: (1) coagulation reactions (extrinsic and intrinsic pathways and fibrinoformation) and (2) platelet function investigations (aggregation, release of Ca++ and ATP after stimulation with collagen 2.5 micrograms/mL). The data obtained with Gd-DTPA meglumine (Mgl) exhibited a significant increase of the intrinsic coagulation pathway and a delay in fibrinoformation, although there is no alteration of the effect of thrombin on fibrinogen (fibrinopeptid A determinations). Platelet aggregation and release are moderately modified. In contrast, Gd-DOTA Mgl exerts no effect on the coagulation system and only minor effects on platelet functions. It is suggested that at least one mechanism involves the complexation of ionized calcium because Gd-DTPA Mgl and Gd-DOTA Mgl complex, respectively, 45% and 23% of ionized calcium in plasma. However, other mechanisms such as an alteration of fibrin polymerization are not unlikely.
已使用以下方法分析了两种钆配合物（钆 - DOTA葡甲胺和钆 - DTPA葡甲胺）与止血功能的相互作用：（1）凝血反应（外源性和内源性途径以及纤维蛋白形成）和（2）血小板功能研究（聚集、用2.5微克/毫升胶原刺激后Ca++和ATP的释放）。用钆 - DTPA葡甲胺（Mgl）获得的数据显示内源性凝血途径显著增加且纤维蛋白形成延迟，尽管凝血酶对纤维蛋白原的作用（纤维蛋白肽A测定）没有改变。血小板聚集和释放受到适度改变。相比之下，钆 - DOTA Mgl对凝血系统无影响，对血小板功能仅有轻微影响。有人提出至少一种机制涉及离子钙的络合，因为钆 - DTPA Mgl和钆 - DOTA Mgl分别络合血浆中45%和23%的离子钙。然而，其他机制如纤维蛋白聚合的改变也有可能。
