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仅有少数因择期冠状动脉搭桥手术而转诊的患者,其危险因素是按照既定指南进行诊断和治疗的。

Only a minority of patients referred for elective coronary artery bypass surgery have risk factors diagnosed and treated according to established guidelines.

作者信息

Anderson Russell E, Brismar Kerstin, Ivert Torbjörn

机构信息

Section for Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

出版信息

Diab Vasc Dis Res. 2007 Jun;4(2):112-6. doi: 10.3132/dvdr.2007.028.

Abstract

Patients deserve to be medically optimised for treatment of metabolic risk factors and hypertension before referral for elective coronary artery bypass grafting (CABG). We describe here a prospective study of 347 consecutive patients referred for elective CABG. An oral glucose tolerance test (OGTT) was performed and metabolic risk factors and hypertension were determined pre-operatively. Compliance to treatment guidelines was calculated. From the total of 347 patients, 80 patients (23%) had known and 66 (19%) had previously unknown diabetes. Dysglycaemia (that is, diabetes and pre-diabetes) was found in 194 (73%) of the 267 patients without known diabetes. Among patients with dysglycaemia, 111/274 (41%) received one antihypertensive medication, or none, and blood pressure guidelines were met in 39/274 (14%); statins were being taken by 206 (75%; average dose 23 mg simvastatin) and low-density lipoprotein (LDL)-cholesterol guidelines were met in 43 (16%). In conclusion, diabetes diagnosis and titration of risk factor treatment to guidelines is inadequate even in elective CABG patients. A pre-admission OGTT affords an opportunity to improve care significantly.

摘要

在转介进行择期冠状动脉搭桥术(CABG)之前,患者应在医学上对代谢危险因素和高血压进行优化治疗。我们在此描述了一项对347例连续接受择期CABG治疗的患者进行的前瞻性研究。进行了口服葡萄糖耐量试验(OGTT),并在术前确定了代谢危险因素和高血压。计算了对治疗指南的依从性。在总共347例患者中,80例(23%)患有已知糖尿病,66例(19%)此前患有未知糖尿病。在267例无已知糖尿病的患者中,194例(73%)存在血糖异常(即糖尿病和糖尿病前期)。在血糖异常的患者中,111/274(41%)服用一种或未服用任何抗高血压药物,39/274(14%)符合血压指南;206例(75%;辛伐他汀平均剂量23mg)正在服用他汀类药物,43例(16%)符合低密度脂蛋白(LDL)胆固醇指南。总之,即使在择期CABG患者中,糖尿病诊断和将危险因素治疗调整至指南的情况也不充分。入院前的OGTT提供了显著改善治疗的机会。

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