Anderson Russell E, Brismar Kerstin, Ivert Torbjörn
Section for Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Diab Vasc Dis Res. 2007 Jun;4(2):112-6. doi: 10.3132/dvdr.2007.028.
Patients deserve to be medically optimised for treatment of metabolic risk factors and hypertension before referral for elective coronary artery bypass grafting (CABG). We describe here a prospective study of 347 consecutive patients referred for elective CABG. An oral glucose tolerance test (OGTT) was performed and metabolic risk factors and hypertension were determined pre-operatively. Compliance to treatment guidelines was calculated. From the total of 347 patients, 80 patients (23%) had known and 66 (19%) had previously unknown diabetes. Dysglycaemia (that is, diabetes and pre-diabetes) was found in 194 (73%) of the 267 patients without known diabetes. Among patients with dysglycaemia, 111/274 (41%) received one antihypertensive medication, or none, and blood pressure guidelines were met in 39/274 (14%); statins were being taken by 206 (75%; average dose 23 mg simvastatin) and low-density lipoprotein (LDL)-cholesterol guidelines were met in 43 (16%). In conclusion, diabetes diagnosis and titration of risk factor treatment to guidelines is inadequate even in elective CABG patients. A pre-admission OGTT affords an opportunity to improve care significantly.
在转介进行择期冠状动脉搭桥术(CABG)之前,患者应在医学上对代谢危险因素和高血压进行优化治疗。我们在此描述了一项对347例连续接受择期CABG治疗的患者进行的前瞻性研究。进行了口服葡萄糖耐量试验(OGTT),并在术前确定了代谢危险因素和高血压。计算了对治疗指南的依从性。在总共347例患者中,80例(23%)患有已知糖尿病,66例(19%)此前患有未知糖尿病。在267例无已知糖尿病的患者中,194例(73%)存在血糖异常(即糖尿病和糖尿病前期)。在血糖异常的患者中,111/274(41%)服用一种或未服用任何抗高血压药物,39/274(14%)符合血压指南;206例(75%;辛伐他汀平均剂量23mg)正在服用他汀类药物,43例(16%)符合低密度脂蛋白(LDL)胆固醇指南。总之,即使在择期CABG患者中,糖尿病诊断和将危险因素治疗调整至指南的情况也不充分。入院前的OGTT提供了显著改善治疗的机会。