新鲜鱼腥草中酚类化学成分的研究

[Studies on chemical constituents of phenols in fresh Houttuynia cordata].

作者信息

Meng Jiang, Dong Xiao-Ping, Zhou Yi-Sheng, Jiang Zhi-Hong, Leung Sze-Yin Kelvin, Zhao Zhong-Zhen

机构信息

GuangDong Pharmaceutical University, Guangzhou 510000, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):929-31.

PMID:17655149

Abstract

OBJECTIVE

To study the aqueous constituents of Houttuynia cordata.

METHOD

Various columns including Diaion HP-20, Sephadex LH-20, ODS and silica gel were employed for the isolation and purification of compounds from H. cordata. The structures of the compounds were identified by physiochemical properties and spectral analysis.

RESULT

Five compounds were isolated, and their structures were identified as chlorogenic methyl ester (1), (E)-4-Hydroxy-4-[3'-(beta-D-glucopyranosyloxy) butylidene]-3, 5, 5-trimethyl-2-cyclohexen-1-one (2), 2-(3, 4-dihydroxyphenyl) ethyl-beta-D-glucopyranoside (3), p-hydroxyphenethyl-beta-D-glucoside (4), 4-(beta-D-glucopyranosyloxy)-3-hydroxy-Benzoic acid (5).

CONCLUSION

All compounds were isolated from this plant for the first time.

摘要

目的

研究鱼腥草的水相成分。

方法

采用多种色谱柱，包括Diaion HP - 20、Sephadex LH - 20、ODS和硅胶，从鱼腥草中分离纯化化合物。通过理化性质和光谱分析鉴定化合物的结构。

结果

分离得到5个化合物，其结构分别鉴定为绿原酸甲酯（1）、（E）-4 - 羟基 - 4 - [3' - （β - D - 吡喃葡萄糖氧基）亚丁基] - 3,5,5 - 三甲基 - 2 - 环己烯 - 1 - 酮（2）、2 - （3,4 - 二羟基苯基）乙基 - β - D - 吡喃葡萄糖苷（3）、对羟基苯乙基 - β - D - 葡萄糖苷（4）、4 - （β - D - 吡喃葡萄糖氧基） - 3 - 羟基苯甲酸（5）。