Liu Yue-Li, Lü Jun-Hua
School of Pharmacy, Jinan University, Guangzhou 510632, China.
Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):940-3.
To observe the protecting actions of Peristrophe roxburghiane on liver functions and structure in fatty liver rats caused by insulin resistance.
High-fat-sugar diet was fed in rats to produce insulin resistance and fatty liver model, and then P. roxburghiane was administered for 8 weeks, and the rats were killed and the blood was sampled to measure the levels of FFA, TC, TG, HDL-C and LDL-C, and the activities of AST, ALT. The fasting serum glucose (FBG) and insulin were measured, and insulin-sensitivity index was calculated. The liver was weighed and collected to calculate liver index and measured the activities of GSH-PX, SOD, CAT and the amount of MDA.
High and low dosage of P. roxburghiane can decrease the levels of FFA, TG and increase the level of HDL-C, reduce the activities of ALT, AST and liver index, and reduce the damaged degree of the liver tissue significantly. High and low dosage of P. roxburghiane can significantly enhance the activities of SOD, CAT, and GSH-PX, reduce the amount of MDA.
P. roxburghiane possesses regulating action on the serum lipid, blood glucose and insulin, and improving liver functions of fatty liver rats induced by high-fat-sugar diet, and the acting mechanism may be concerned with enhanced antioxidative ability.
观察红丝线草对胰岛素抵抗所致脂肪肝大鼠肝功能及肝脏结构的保护作用。
采用高脂高糖饮食喂养大鼠以建立胰岛素抵抗和脂肪肝模型，然后给予红丝线草灌胃8周，处死大鼠并取血，检测游离脂肪酸（FFA）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平，以及天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）活性。测定空腹血糖（FBG）和胰岛素水平，并计算胰岛素敏感指数。称取肝脏重量并收集，计算肝脏指数，检测谷胱甘肽过氧化物酶（GSH-PX）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活性及丙二醛（MDA）含量。
红丝线草高、低剂量组均可降低FFA、TG水平，升高HDL-C水平，降低ALT、AST活性及肝脏指数，显著减轻肝组织损伤程度。红丝线草高、低剂量组均可显著提高SOD、CAT、GSH-PX活性，降低MDA含量。
红丝线草对高脂高糖饮食诱导的脂肪肝大鼠的血脂、血糖及胰岛素具有调节作用，可改善其肝功能，作用机制可能与增强抗氧化能力有关。
