Wang Jian-Qing, Li Jun, Zou Yu-Hong, Cheng Wen-Ming, Lu Chao, Zhang Lei, Ge Jin-Fang, Huang Cheng, Jin Yong, Lv Xiong-Wen, Hu Cheng-Mu, Liu Li-Ping
School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.
J Ethnopharmacol. 2009 Jan 12;121(1):54-60. doi: 10.1016/j.jep.2008.09.029. Epub 2008 Oct 8.
To evaluate the protective effects of total flavonoids of Litsea Coreana leve (TFLC) on rat high fat diet-induced hepatic steatosis model.
Rats were given either a high fat diet alone or the same diet plus TFLC for 4 weeks.
TFLC improved liver histology with reduced serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as decreased the over accumulation lipids in serum and liver. TFLC increased serum levels of leptin and insulin, while decreased serum TNFalpha level in high fat diet fed rat. Furthermore, TFLC was found increased the expression of peroxisome proliferator-activated receptor alpha (PPARalpha) in high fat diet fed rat liver. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in high fat diet fed rat liver.
TFLC exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions, improving the adipocytokines release and increasing the expression of PPARalpha.
评估朝鲜木姜子总黄酮（TFLC）对大鼠高脂饮食诱导的肝脂肪变性模型的保护作用。
大鼠分别给予单纯高脂饮食或高脂饮食加TFLC，持续4周。
TFLC改善了肝脏组织学，降低了血清丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平，减少了血清和肝脏中脂质的过度蓄积。TFLC增加了高脂饮食喂养大鼠血清中瘦素和胰岛素水平，同时降低了血清肿瘤坏死因子α水平。此外，发现TFLC增加了高脂饮食喂养大鼠肝脏中过氧化物酶体增殖物激活受体α（PPARα）的表达。这些益处与高脂饮食喂养大鼠肝脏中超氧化物歧化酶（SOD）增加和丙二醛（MDA）减少有关。
TFLC对高脂饮食喂养的大鼠肝脂肪变性具有保护作用，可能是通过其抗氧化作用、改善脂肪细胞因子释放以及增加PPARα的表达来实现的。
