Ch'ng Chin Wei, Fitzgerald Mark, Gerostamoulos Jim, Cameron Peter, Bui Dinh, Drummer Olaf H, Potter Jeremy, Odell Morris
Alfred Hospital, Melbourne, Victoria, Australia. W.Ch'
Emerg Med Australas. 2007 Aug;19(4):359-65. doi: 10.1111/j.1742-6723.2007.00958.x.
To determine the drug use in injured Victorian drivers involved in motor vehicle collisions and subsequently transported to a major adult trauma centre in Victoria.
A blood sample was obtained from patients who had been taken to The Alfred Emergency & Trauma Centre (Prahran, Vic., Australia) following a motor vehicle collision. This was performed at the same time and under the same law as compulsory blood screening in Victoria (Section 56 of the Road Safety Act). Four hundred and thirty-six specimens were analysed. Blood stored in vacutainer tubes containing preservative were screened for drugs using enzyme-linked immunosorbent assay and gas chromatography-mass spectometry analysis. Medically administered drugs were excluded from the results.
Four hundred and thirty-six specimens were analysed. Metabolites of cannabis were the most commonly found drug (46.7%), the active form of cannabis (Delta9-tetrahydrocannabinol) was found in 33 specimens (7.6%). The next most prevalent drugs were benzodiazepines (15.6%), opiates (11%), amphetamines (4.1%) and methadone (3%). Cocaine was detected in 1.4% of cases. Of the motor vehicle collisions 66% involved males and females of 15-44 years old and Delta9-tetrahydrocannabinol was almost exclusively found in this age group. In motor vehicle collisions involving older drivers there was an increasing use of benzodiazepines. In women >65 years old 30% were positive for benzodiazepines.
Drug usage found in this group of injured drivers was disturbingly high. The introduction of further initiatives to decrease the prevalence of drug use in motor vehicle drivers is required.
确定维多利亚州发生机动车碰撞事故并随后被送往该州一家主要成人创伤中心的受伤驾驶员的药物使用情况。
从机动车碰撞事故后被送往阿尔弗雷德紧急与创伤中心(澳大利亚维多利亚州普拉兰)的患者身上采集血样。这与维多利亚州强制血液筛查在同一时间且依据同一法律进行(《道路安全法》第56条)。共分析了436份样本。使用酶联免疫吸附测定法和气相色谱 - 质谱分析法对储存在含有防腐剂的真空采血管中的血液进行药物筛查。结果中排除了医疗用药物。
共分析了436份样本。大麻代谢物是最常检测到的药物(46.7%),在33份样本中发现了大麻的活性形式(Δ9 - 四氢大麻酚)(7.6%)。其次最常见的药物是苯二氮䓬类(15.6%)、阿片类(11%)、苯丙胺类(4.1%)和美沙酮(3%)。在1.4%的病例中检测到可卡因。在机动车碰撞事故中,66%涉及15 - 44岁的男性和女性,且几乎仅在这个年龄组中发现了Δ9 - 四氢大麻酚。在涉及年长驾驶员的机动车碰撞事故中,苯二氮䓬类药物的使用呈上升趋势。在65岁以上的女性中,30%的人苯二氮䓬类药物检测呈阳性。
这组受伤驾驶员中的药物使用率高得令人不安。需要采取进一步举措来降低机动车驾驶员中药物使用的流行率。