大叶桃花心木茎皮中的柠檬苦素类化合物。

Limonoids from the stem bark of Khaya grandifoliola.

作者信息

Zhang Hua, Odeku Oluwatoyin A, Wang Xiao-Ning, Yue Jian-Min

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

出版信息

Phytochemistry. 2008 Jan;69(1):271-5. doi: 10.1016/j.phytochem.2007.06.009. Epub 2007 Jul 25.

DOI:10.1016/j.phytochem.2007.06.009

PMID:17655891

Abstract

Three limonoids, deacetylkhayanolide E (1), 6S-hydroxykhayalactone (2), and grandifolide A (3), along with three known ones, were isolated from stem bark of the Nigerian medicinal plant Khaya grandifoliola. Their structures were characterized on the basis of the application of spectroscopic methods. In vitro antimicrobial and cytotoxic activities of the isolates were also tested, but were all found to be inactive.

摘要

从尼日利亚药用植物大叶卡雅楝的茎皮中分离出三种柠檬苦素，即去乙酰卡雅诺内酯E（1）、6S-羟基卡雅内酯（2）和大叶楝素A（3），以及三种已知的柠檬苦素。通过光谱方法对它们的结构进行了表征。还测试了这些分离物的体外抗菌和细胞毒性活性，但发现它们均无活性。