Khayseneganins A-H，来自非洲崖豆的 limonoids。

Khayseneganins A-H, limonoids from Khaya senegalensis.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

出版信息

J Nat Prod. 2013 Mar 22;76(3):327-33. doi: 10.1021/np3006919. Epub 2012 Dec 4.

DOI:10.1021/np3006919

PMID:23210623

Abstract

Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#), all with a MIC value of 12.5 μg/mL.

摘要

从非洲桃花心木的叶和小枝中分离得到了 8 个新的柠檬苦素，khayseneganins A-H（1-8）和 31 个已知的柠檬苦素。通过二维 NMR 光谱和质谱确定了新化合物的结构，并用 CD 外消旋手性方法确定了 1 的绝对构型。化合物 9、10、12 和 15 对铜绿假单胞菌、MRSA 92（#）和 MRSA 98（#）均具有抗菌活性，MIC 值均为 12.5 μg/mL。