State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
J Nat Prod. 2013 Mar 22;76(3):327-33. doi: 10.1021/np3006919. Epub 2012 Dec 4.
Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#), all with a MIC value of 12.5 μg/mL.
从非洲桃花心木的叶和小枝中分离得到了 8 个新的柠檬苦素，khayseneganins A-H（1-8）和 31 个已知的柠檬苦素。通过二维 NMR 光谱和质谱确定了新化合物的结构，并用 CD 外消旋手性方法确定了 1 的绝对构型。化合物 9、10、12 和 15 对铜绿假单胞菌、MRSA 92（#）和 MRSA 98（#）均具有抗菌活性，MIC 值均为 12.5 μg/mL。
