活化诱导的无反应性（失能）限制了CD8 T细胞对肿瘤的反应。
Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors.
作者信息
Mescher Matthew F, Popescu Flavia E, Gerner Michael, Hammerbeck Chris D, Curtsinger Julie M
机构信息
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street S.E., Minneapolis, MN 55455, USA.
出版信息
Semin Cancer Biol. 2007 Aug;17(4):299-308. doi: 10.1016/j.semcancer.2007.06.008. Epub 2007 Jun 23.
Abstract
Naïve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-gamma production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.
摘要
初始CD8 T细胞通过增殖和分化对由抗原、共刺激和细胞因子提供的信号作出反应，以发展效应功能。然而，在初始克隆扩增之后，这些细胞会产生活化诱导的无反应性（AINR），这是一种无反应状态，其特征是无法产生白细胞介素-2。处于AINR状态的细胞可以执行效应功能（细胞溶解、γ干扰素产生），但面对持续存在的抗原时无法继续增殖和扩增。AINR限制了活化的细胞毒性T淋巴细胞控制肿瘤生长的能力，但可以通过治疗性给予或由活化的CD4辅助性T细胞提供白细胞介素-2来逆转，从而允许持续扩增。
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