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Monosomy 7 in t(9;22)-negative cells during nilotinib therapy in an imatinib-resistant chronic myeloid leukemia case.

作者信息

Zeidan Amer, Kakati Surabhi, Anderson Barbara, Barcos Maurice, Wetzler Meir

出版信息

Cancer Genet Cytogenet. 2007 Jul 15;176(2):169-71. doi: 10.1016/j.cancergencyto.2006.12.011.

DOI:10.1016/j.cancergencyto.2006.12.011
PMID:17656263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2717791/
Abstract
摘要

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1
Monosomy 7 in t(9;22)-negative cells during nilotinib therapy in an imatinib-resistant chronic myeloid leukemia case.在一例对伊马替尼耐药的慢性髓性白血病患者的尼罗替尼治疗期间，t(9;22)阴性细胞中出现7号染色体单体。
Cancer Genet Cytogenet. 2007 Jul 15;176(2):169-71. doi: 10.1016/j.cancergencyto.2006.12.011.
2
Presence of complex t(6;9;22;15) four-way chromosome rearrangement plus rare t(1;6) translocation with favorable response to imatinib therapy in chronic myelogenous leukemia.慢性粒细胞白血病中存在复杂的t(6;9;22;15)四向染色体重排以及罕见的t(1;6)易位，对伊马替尼治疗反应良好。
Leuk Lymphoma. 2011 Nov;52(11):2182-4. doi: 10.3109/10428194.2011.585674. Epub 2011 Jun 30.
3
t(5;6;12) associated with resistance to imatinib mesylate in chronic myeloid leukemia.与慢性髓性白血病中对甲磺酸伊马替尼耐药相关的t(5;6;12)
Int J Hematol. 2009 May;89(4):508-512. doi: 10.1007/s12185-009-0275-8. Epub 2009 Mar 26.
4
Deletion of the der(9q) in chronic myeloid leukemia: the controversy continues.慢性髓性白血病中9号染色体衍生染色体（der(9q)）的缺失：争议仍在继续。
Leuk Lymphoma. 2009 Jun;50(6):871-2. doi: 10.1080/10428190902980889.
5
Successful Nilotinib therapy in an imatinib-resistant chronic myeloid leukemia patient displaying an intron-derived insertion/truncation mutation in the BCR-ABL kinase domain.
Leuk Res. 2009 Sep;33(9):e157-8. doi: 10.1016/j.leukres.2009.03.040. Epub 2009 Apr 29.
6
Chronic myeloid leukemia with a novel four-way t(6;13;9;22)(p21;q32;q34;q11.2) successfully treated with imatinib mesylate.采用甲磺酸伊马替尼成功治疗的伴有新型四重t(6;13;9;22)(p21;q32;q34;q11.2)的慢性髓性白血病
Cancer Genet Cytogenet. 2010 Sep;201(2):135-6. doi: 10.1016/j.cancergencyto.2010.05.017.
7
Neutrophil numerals.中性粒细胞数量
Blood. 2014 Mar 13;123(11):1635. doi: 10.1182/blood-2013-12-541797.
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Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: two cases with a different outcome.在费城染色体阳性慢性髓性白血病的伊马替尼治疗过程中发生的伴有严重骨髓发育异常的7号染色体单体：两例不同结局的病例
Am J Hematol. 2007 Sep;82(9):849-51. doi: 10.1002/ajh.20859.
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Emergence of Ph negative clones in chronic myeloid leukemia (CML) patients in complete cytogenetic remission after therapy with imatinib mesylate (STI).在接受甲磺酸伊马替尼（STI）治疗后达到细胞遗传学完全缓解的慢性髓性白血病（CML）患者中出现Ph阴性克隆。
Eur J Haematol. 2003 Oct;71(4):313-4. doi: 10.1034/j.1600-0609.2003.00148.x.
10
Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase.尼洛替尼与伊马替尼相比，可降低新诊断的慢性期慢性髓性白血病患者的 BCR-ABL 突变发生率。
Blood. 2013 May 2;121(18):3703-8. doi: 10.1182/blood-2012-04-423418. Epub 2013 Mar 15.

引用本文的文献

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[Philadelphia chromosome-negative myeloid neoplasms in patients with Philadelphia chromosome-positive chronic myeloid leukemia during tyrosine kinase inhibtor-therapy].[酪氨酸激酶抑制剂治疗期间费城染色体阳性慢性髓性白血病患者中的费城染色体阴性髓系肿瘤]
Zhonghua Xue Ye Xue Za Zhi. 2019 Jul 14;40(7):547-553. doi: 10.3760/cma.j.issn.0253-2727.2019.07.003.
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[Myelodysplastic syndrome with Philadelphia negative+8 clonal chromosomal abnormalities after tyrosine kinase inhibitors therapy for chronic myeloid leukemia: a case report and literature].慢性髓性白血病酪氨酸激酶抑制剂治疗后伴费城阴性+8克隆性染色体异常的骨髓增生异常综合征：一例报告及文献
Zhonghua Xue Ye Xue Za Zhi. 2019 Aug 14;40(8):697-699. doi: 10.3760/cma.j.issn.0253-2727.2019.08.017.
3
Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia.费城染色体阴性中期染色体 7 克隆异常预后不良及慢性髓性白血病潜在骨髓增生异常特征的相关性。
Haematologica. 2019 Jun;104(6):1150-1155. doi: 10.3324/haematol.2018.208801. Epub 2018 Dec 20.
4
[Clinical observation of chromosomal abnormalities in Ph negative cells of chronic myeloid leukemia patients treated with tyrosine kinase inhibitors].[酪氨酸激酶抑制剂治疗慢性髓性白血病患者Ph阴性细胞染色体异常的临床观察]
Zhonghua Xue Ye Xue Za Zhi. 2016 May 14;37(5):412-6. doi: 10.3760/cma.j.issn.0253-2727.2016.05.011.
5
Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: a case report.尼洛替尼治疗期间慢性粒细胞白血病患者出现短暂性7号染色体单体：一例报告
Clin Case Rep. 2016 Feb 8;4(3):282-6. doi: 10.1002/ccr3.506. eCollection 2016 Mar.
6
Emergence of abnormal clone with monsomy 7 in Philadelphia negative cells of CML patients treated with tyrosine kinase inhibitors.接受酪氨酸激酶抑制剂治疗的慢性粒细胞白血病患者费城染色体阴性细胞中出现伴有7号染色体单体的异常克隆。
Int J Hematol. 2009 Jan;89(1):123-125. doi: 10.1007/s12185-008-0224-y. Epub 2008 Dec 18.

本文引用的文献

1
Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors.慢性髓性白血病患者伊马替尼治疗后出现的费城染色体阴性克隆性造血：9例报告及预测因素分析
Cancer Genet Cytogenet. 2006 Oct 1;170(1):16-23. doi: 10.1016/j.cancergencyto.2006.04.012.
2
Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia.慢性粒细胞白血病接受甲磺酸伊马替尼治疗后发生的骨髓增生异常综合征和急性白血病。
Blood. 2006 Oct 15;108(8):2811-3. doi: 10.1182/blood-2006-04-017400. Epub 2006 Jun 29.
3
Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia.伊马替尼治疗费城染色体阳性慢性髓性白血病期间费城染色体阴性细胞中克隆性染色体异常的34例患者报告
Leukemia. 2004 Aug;18(8):1340-6. doi: 10.1038/sj.leu.2403399.
4
Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase.在慢性期费城染色体阳性慢性髓性白血病患者接受甲磺酸伊马替尼治疗期间出现的费城染色体阴性中期的染色体异常。
Cancer. 2003 Nov 1;98(9):1905-11. doi: 10.1002/cncr.11729.
5
Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority.在一些接受伊马替尼治疗后处于细胞遗传学缓解期的慢性粒细胞白血病患者中，Ph-细胞出现克隆性细胞遗传学异常，但大多数患者恢复了多克隆造血。
Blood. 2003 Mar 1;101(5):1941-9. doi: 10.1182/blood-2002-07-2053. Epub 2002 Oct 31.
6
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.在对DNA损伤的凋亡反应中，p73受酪氨酸激酶c-Abl调控。
Nature. 1999 Jun 24;399(6738):814-7. doi: 10.1038/21704.
7
Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases.慢性髓性白血病患者在α干扰素诱导完全细胞遗传学缓解后出现新的克隆性异常：三例报告
Leukemia. 1997 May;11(5):767-71. doi: 10.1038/sj.leu.2400642.
8
Interaction between ATM protein and c-Abl in response to DNA damage.DNA损伤反应中ATM蛋白与c-Abl之间的相互作用。
Nature. 1997 May 29;387(6632):520-3. doi: 10.1038/387520a0.
9
Chronic myeloid leukemia with permanent disappearance of the Ph1 chromosome and development of new clonal subpopulations.慢性髓性白血病伴Ph1染色体永久消失及新克隆亚群的出现。
Blood. 1979 Jan;53(1):1-14.