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尼洛替尼治疗期间慢性粒细胞白血病患者出现短暂性7号染色体单体：一例报告

Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: a case report.

作者信息

Jawad Majd D, Go Ronald S, Ketterling Rhett P, Begna Kebede H, Reichard Kaaren K, Shi Min

机构信息

Division of Hematology Mayo Clinic Rochester Minnesota.

Division of Laboratory Genetics Mayo Clinic Rochester Minnesota.

出版信息

Clin Case Rep. 2016 Feb 8;4(3):282-6. doi: 10.1002/ccr3.506. eCollection 2016 Mar.

DOI:10.1002/ccr3.506
PMID:27014453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4771850/
Abstract

Tyrosine kinase inhibitor treated chronic myelogenous leukemia patients with monosomy 7 arising in Philadelphia chromosome negative (Ph-) cells tend to evolve into MDS/AML. However, monosomy 7 in Ph- cells can be a transient finding, and it is not an absolute indication of the emergence of a new myeloid malignancy.

摘要

酪氨酸激酶抑制剂治疗的慢性髓性白血病患者，若费城染色体阴性（Ph-）细胞中出现7号染色体单体，则往往会演变为骨髓增生异常综合征/急性髓系白血病。然而，Ph-细胞中的7号染色体单体可能是一个短暂的发现，并非新的髓系恶性肿瘤出现的绝对指征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cb/4771850/eb8f1576b541/CCR3-4-282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cb/4771850/eb8f1576b541/CCR3-4-282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84cb/4771850/eb8f1576b541/CCR3-4-282-g001.jpg

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本文引用的文献

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Clonal chromosomal abnormalities in Philadelphia-negative cells in chronic myeloid leukemia patients treated with nilotinib used in first-line therapy.慢性髓性白血病患者在一线治疗中使用尼洛替尼时，费城染色体阴性细胞中的克隆染色体异常。
Ann Hematol. 2013 Dec;92(12):1625-32. doi: 10.1007/s00277-013-1816-z. Epub 2013 Jun 23.
2
Factors influencing a second myeloid malignancy in patients with Philadelphia-negative -7 or del(7q) clones during tyrosine kinase inhibitor therapy for chronic myeloid leukemia.慢性髓性白血病患者在酪氨酸激酶抑制剂治疗期间，费城染色体阴性 -7 或 del(7q) 克隆影响二次髓系恶性肿瘤发生的相关因素
Cancer Genet. 2011 Jan;204(1):39-44. doi: 10.1016/j.cancergencyto.2010.08.017.
3
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia.
尼洛替尼与伊马替尼用于治疗新诊断的慢性髓性白血病。
N Engl J Med. 2010 Jun 17;362(24):2251-9. doi: 10.1056/NEJMoa0912614. Epub 2010 Jun 5.
4
Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.达沙替尼治疗的慢性髓性白血病在费城阴性细胞中迅速发展为伴有7号染色体单体的急性髓性白血病的基因分析。
Cancer Genet Cytogenet. 2010 Jun;199(2):89-95. doi: 10.1016/j.cancergencyto.2010.02.005.
5
Hyperleukocytotic secondary acute myeloid leukemia (AML) with sole monosomy 7 as sequela of Philadelphia-chromosome positive chronic myeloid leukemia (CML).作为费城染色体阳性慢性髓性白血病（CML）后遗症的伴有单纯7号染色体单体的高白细胞性继发性急性髓系白血病（AML）。
Eur J Haematol. 2009 Dec 1;83(6):611-2. doi: 10.1111/j.1600-0609.2009.01335.x. Epub 2009 Aug 13.
6
The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells.费城染色体阴性细胞中存在克隆性细胞遗传学异常的慢性髓性白血病患者的预后。
Cancer. 2007 Oct 1;110(7):1509-19. doi: 10.1002/cncr.22936.
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Characterization of Ph-negative abnormal clones emerging during imatinib therapy.伊马替尼治疗期间出现的Ph阴性异常克隆的特征分析。
Cancer. 2007 Jun 15;109(12):2466-72. doi: 10.1002/cncr.22699.