Pillay Deenan
Department of Infection, University College London, London W1T 4JF, UK.
J Antimicrob Chemother. 2007 Aug;60 Suppl 1:i57-8. doi: 10.1093/jac/dkm159.
The number of available antiviral drugs is growing fast. The emergence of drug-resistant viruses is well documented as a cause for drug failure. Such viruses also carry the potential for transmission, the risks for which vary according to specific viral transmission dynamics. This potential is best described for HIV and influenza. Resistance to the new generation of hepatitis C virus inhibitors is also likely to become a cause for concern. The priorities for future action to limit resistance include application of sophisticated surveillance mechanisms linked to detailed virological data, development of optimal treatment regimens (e.g. combination therapies) to limit emergence of resistance, and a focus on prevention strategies to prevent transmission.
可用抗病毒药物的数量正在迅速增加。耐药病毒的出现已被充分证明是药物治疗失败的一个原因。此类病毒还具有传播潜力，其风险根据特定的病毒传播动态而有所不同。这一潜力在艾滋病毒和流感方面描述得最为清楚。对新一代丙型肝炎病毒抑制剂的耐药性也可能成为一个令人担忧的问题。未来限制耐药性的行动重点包括应用与详细病毒学数据相关的精密监测机制、制定最佳治疗方案（如联合疗法）以限制耐药性的出现，以及着重采取预防策略来防止传播。
