Littler Eddy
Medivir UK Ltd, Chesterford Research Park, Little Chesterford, Essex, CB10 1XL, UK.
IDrugs. 2004 Dec;7(12):1104-12.
A review of the history, development and current status of antiviral chemotherapy is presented from its origins in the 1960s until the present day. Key issues in the development of novel antivirals are the emergence of resistant virus, safety and side effects. This review describes the current therapeutic status of the herpes viruses, HIV, hepatitis viruses and respiratory viruses, and outlines the current limitations in the field together with the future compounds likely to emerge to address these needs. The future of antiviral research is assessed in relation to the impact of potential 'emerging viruses' and biological weapons, and the potential of combination therapies involving antivirals and disease modification.
本文综述了抗病毒化疗从20世纪60年代起源至今的历史、发展及现状。新型抗病毒药物研发中的关键问题是耐药病毒的出现、安全性和副作用。本综述描述了疱疹病毒、艾滋病毒、肝炎病毒和呼吸道病毒的当前治疗状况，概述了该领域目前的局限性以及可能出现的满足这些需求的未来化合物。结合潜在“新兴病毒”和生物武器的影响以及涉及抗病毒药物和疾病修饰的联合疗法的潜力，对抗病毒研究的未来进行了评估。
