Tuckerman E, Laird S M, Prakash A, Li T C
Biomedical Research Unit, Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK.
Hum Reprod. 2007 Aug;22(8):2208-13. doi: 10.1093/humrep/dem141.
Studies in mice suggest that CD56 + uterine natural killer (uNK) cells play an important role in implantation. Studies in humans have described an increase in the number of uNK cells in the non-pregnant mid-secretory endometrium of women with unexplained recurrent miscarriage (RM). However, the predictive value of uNK cell number in the maintenance of pregnancy is controversial.
A blind retrospective study was undertaken. The percentage of stromal cells positive for CD56 was identified by immunocytochemistry in endometrial biopsies from 10 normal control women and 87 women with unexplained RM, of whom 51 became pregnant following biopsy. Biopsies were obtained on days LH + 7 to LH + 9.
As in previous studies, the number of uNK cells in the 87 women with RM (mean 11.2% range 1.1-41.4%) was significantly higher (P = 0.013) than in the control women (mean 6.2% range 2.2-13.9%). No significance difference in uNK numbers was observed between 19 women who miscarried (mean 9.6% range 1.7-25.0%) and 32 women who had a live birth (mean 13.3% range 1.1-41.4%) in a subsequent pregnancy.
In this study numbers of uNK cells in the peri-implantation endometrium of women with unexplained recurrent miscarriage did not predict subsequent pregnancy outcome.
对小鼠的研究表明，CD56 +子宫自然杀伤（uNK）细胞在着床过程中发挥重要作用。对人类的研究描述了不明原因复发性流产（RM）女性非妊娠中期分泌期子宫内膜中uNK细胞数量增加。然而，uNK细胞数量对维持妊娠的预测价值存在争议。
进行了一项盲法回顾性研究。通过免疫细胞化学法确定10名正常对照女性和87名不明原因RM女性子宫内膜活检中CD56阳性基质细胞的百分比，其中51名女性在活检后怀孕。在LH + 7至LH + 9天获取活检组织。
与先前研究一样，87名RM女性的uNK细胞数量（平均11.2%，范围1.1 - 41.4%）显著高于对照女性（平均6.2%，范围2.2 - 13.9%）（P = 0.013）。在随后妊娠中流产的19名女性（平均9.6%，范围1.7 - 25.0%）和活产的32名女性（平均13.3%，范围1.1 - 41.4%）之间，未观察到uNK细胞数量的显著差异。
在本研究中，不明原因复发性流产女性着床期子宫内膜中的uNK细胞数量不能预测随后的妊娠结局。
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