Schutte Aletta E, Huisman Hugo W, Schutte Rudolph, Malan Leoné, van Rooyen Johannes M, Malan Nico T, Schwarz Peter E H
School for Physiology, Nutrition and Consumer Sciences, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom 2520, South Africa.
Eur J Endocrinol. 2007 Aug;157(2):181-8. doi: 10.1530/EJE-07-0044.
Concentrations of adiponectin, an adipocytokine with insulin-sensitizing actions, may vary according to ethnic group. This study aimed to determine whether fasting adiponectin levels of Caucasian and African women differ. A second objective was to determine which components of the metabolic syndrome are more closely related to adiponectinemia in both groups.
A cross-sectional study including 102 urban African and 115 Caucasian women with a wide range of obesity aged 20-55 years.
Anthropometric measurements were taken, namely weight, height, body mass index, waist circumference, and hip circumference. Cardiovascular measurements included blood pressure and arterial compliance. Fasting blood samples were taken to determine glucose, insulin, C-peptide, leptin, adiponectin, and lipid levels.
Mean adiponectin levels of the whole groups did not differ, but normal weight African women (N = 38) showed marginally lower adiponectin levels than their Caucasian counterparts (N = 41; P = 0.047). No differences in adiponectin were shown for overweight and obese women. Separate multiple regression analyses for ethnic groups showed that only homeostasis model assessment-insulin resistance (HOMA-IR) significantly contributed to the variance in adiponectin levels of African women, whereas leptin, triacylglycerol levels and HOMA-IR contributed significantly to adiponectin variance in Caucasian women. An additional multiple regression analysis in a combined ethnic group (N = 217) showed ethnicity to be a significant contributor to variances in adiponectin levels.
Even though adiponectin levels of these ethnic groups are similar, different associations of adiponectin with leptin and triacylglycerol levels might indicate that there are ethnic differences regarding the mechanistic functions of adiponectin within the scope of the metabolic syndrome.
脂联素是一种具有胰岛素增敏作用的脂肪细胞因子，其浓度可能因种族而异。本研究旨在确定白种女性和非洲裔女性的空腹脂联素水平是否存在差异。第二个目的是确定代谢综合征的哪些组成部分与两组的脂联素血症关系更为密切。
一项横断面研究，纳入了102名年龄在20 - 55岁、肥胖程度各异的城市非洲裔女性和115名白种女性。
进行人体测量，即体重、身高、体重指数、腰围和臀围。心血管测量包括血压和动脉顺应性。采集空腹血样以测定血糖、胰岛素、C肽、瘦素、脂联素和血脂水平。
两组的平均脂联素水平无差异，但体重正常的非洲裔女性（N = 38）的脂联素水平略低于白种女性（N = 41；P = 0.047）。超重和肥胖女性的脂联素水平无差异。按种族进行的单独多元回归分析表明，只有稳态模型评估-胰岛素抵抗（HOMA-IR）对非洲裔女性脂联素水平的方差有显著贡献，而瘦素、三酰甘油水平和HOMA-IR对白种女性脂联素方差有显著贡献。对合并种族组（N = 217）进行的额外多元回归分析表明，种族是脂联素水平方差的一个重要影响因素。
尽管这些种族的脂联素水平相似，但脂联素与瘦素和三酰甘油水平的不同关联可能表明，在代谢综合征范围内，脂联素的作用机制存在种族差异。
