Ohman-Hanson Rebecca A, Cree-Green Melanie, Kelsey Megan M, Bessesen Daniel H, Sharp Teresa A, Pyle Laura, Pereira Rocio I, Nadeau Kristen J
Pediatric Endocrinology (R.O.-H., M.C.-G., M.M.K., K.J.N.), University of Colorado School of Medicine, Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado 80045; Endocrinology (D.H.B., R.I.P.), University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045; Colorado School of Public Health at the University of Northern Colorado (T.A.S.), Greeley, Colorado 80639; Department of Pediatrics (L.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; and Department of Biostatistics and Informatics (L.P.), Colorado School of Public Health, Aurora, Colorado 80045.
J Clin Endocrinol Metab. 2016 Dec;101(12):4808-4815. doi: 10.1210/jc.2016-1137. Epub 2016 Sep 7.
Insulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic (H) vs non-Hispanic White (NHW) populations. Adiponectin has a known role in IR, and therefore, understanding ethnic and sex-specific behavior of adiponectin across the lifespan is of clinical significance.
To compare ethnic and sex differences in adiponectin, independent of body mass index, across the lifespan and relationship to IR.
Cross-sectional.
Primary care, referral center.
A total of 187 NHW and 117 H participants (8-57 y) without diabetes. Life stage: pre-/early puberty (Tanner 1/2), midpubertal (Tanner 3/4), late pubertal (Tanner 5, <21 years), and adult (Tanner 5, ≥21).
None.
MAIN OUTCOME MEASURE(S): Fasting adiponectin, insulin, glucose, and revised homeostatic model assessment of insulin resistance.
Adiponectin was significantly inversely correlated with revised homeostatic model assessment of insulin resistance. Regarding puberty, adiponectin trended downward in late puberty, but only males were significantly lower in adulthood. By sex, adiponectin was lower in adult males vs females of both ethnicities. Regarding ethnicity, H adults of both sexes had lower adiponectin than NHW adults. Of note, in NHW females, adiponectin trended highest in adulthood, whereas in H females, adiponectin fell in late puberty and remained lower in adulthood.
Adiponectin inversely correlated with IR, trended down in late puberty, and was lowest in adult males. H adults of both sexes had lower adiponectin than NHW adults, and H females followed a more "male pattern," lacking the rebound in adiponectin seen in NHW females after puberty. These data suggest that adiponectin, independent of body mass index, may relate to the greater cardiometabolic risk seen in H populations and in particular H females.
胰岛素抵抗（IR）和2型糖尿病的发病率正在上升，尤其是在西班牙裔（H）与非西班牙裔白人（NHW）人群中。脂联素在胰岛素抵抗中具有已知作用，因此，了解脂联素在整个生命周期中的种族和性别特异性行为具有临床意义。
比较整个生命周期中独立于体重指数的脂联素的种族和性别差异及其与胰岛素抵抗的关系。
横断面研究。
初级保健转诊中心。
共有187名非西班牙裔白人（NHW）和117名西班牙裔（H）参与者（8至57岁），无糖尿病。生命阶段：青春前期/青春期早期（坦纳1/2期）、青春期中期（坦纳3/4期）、青春期后期（坦纳5期，<21岁）和成年人（坦纳5期，≥21岁）。
无。
空腹脂联素、胰岛素、血糖以及修订的胰岛素抵抗稳态模型评估。
脂联素与修订的胰岛素抵抗稳态模型评估呈显著负相关。关于青春期，脂联素在青春期后期呈下降趋势，但只有成年男性的脂联素显著降低。按性别来看，两个种族的成年男性脂联素均低于成年女性。关于种族，两个性别的西班牙裔成年人脂联素均低于非西班牙裔白人成年人。值得注意的是，在非西班牙裔白人女性中，脂联素在成年期趋于最高，而在西班牙裔女性中，脂联素在青春期后期下降，成年期仍较低。
脂联素与胰岛素抵抗呈负相关，在青春期后期呈下降趋势，在成年男性中最低。两个性别的西班牙裔成年人脂联素均低于非西班牙裔白人成年人，西班牙裔女性遵循更“男性化模式”，缺乏非西班牙裔白人女性青春期后脂联素的反弹。这些数据表明，独立于体重指数的脂联素可能与西班牙裔人群尤其是西班牙裔女性中更高的心脏代谢风险有关。
