Hahn Susanne, Backhaus Manuel, Broecker-Preuss Martina, Tan Susanne, Dietz Tiina, Kimmig Rainer, Schmidt Markus, Mann Klaus, Janssen Onno E
Endokrinologikum Ruhr, Center for Endocrine and Metabolic Diseases, Alter Markt 4, 44866 Bochum, Germany.
Eur J Endocrinol. 2007 Aug;157(2):201-7. doi: 10.1530/EJE-07-0143.
Insulin resistance and obesity are common features of the polycystic ovary syndrome (PCOS). Retinol-binding protein 4 (RBP4), a new fat-derived adipokine, has been described to be elevated in obesity and type 2 diabetes. The aim of the present study was to investigate whether serum RBP4 levels are correlated with metabolic parameters, indices of insulin resistance, and endocrine variables in German PCOS women.
We assessed the correlation between metabolic and endocrine parameters with RBP4 levels in 200 PCOS patients and 64 healthy controls.
Serum RBP4 was measured by enzyme-linked immunosorbent assay (Immundiagnostik AG, Bensheim, Germany). In addition, anthropometric variables, clinical signs of hyperandrogenism, and body fat were evaluated, and a glucose tolerance test was performed to assess parameters of insulin resistance and glucose metabolism.
Taking the entire PCOS cohort, RBP4 levels were positively correlated with body mass index (BMI), body fat, waist circumference, fasting glucose, and area under the curve for glucose (all P<0.05), but not with indices of insulin resistance. On the other hand, PCOS women with impaired glucose metabolism had higher RBP4 levels than PCOS women with normal glucose metabolism (median 30.6, range 23.3-73.9 versus median 26.3, range 6.4-61.4, P<0.05). Furthermore, no differences were found in RBP4 levels between lean PCOS women and BMI-matched healthy controls.
In German PCOS women, serum RBP4 levels are associated with obesity and parameters of glucose metabolism but not with PCOS per se.
胰岛素抵抗和肥胖是多囊卵巢综合征（PCOS）的常见特征。视黄醇结合蛋白4（RBP4）是一种新的脂肪源性脂肪因子，在肥胖和2型糖尿病患者中水平升高。本研究旨在探讨德国PCOS女性血清RBP4水平是否与代谢参数、胰岛素抵抗指标及内分泌变量相关。
我们评估了200例PCOS患者和64例健康对照者的代谢及内分泌参数与RBP4水平之间的相关性。
采用酶联免疫吸附测定法（德国本斯海姆Immundiagnostik AG公司）检测血清RBP4。此外，评估人体测量学变量、高雄激素血症的临床体征和体脂，并进行葡萄糖耐量试验以评估胰岛素抵抗和葡萄糖代谢参数。
在整个PCOS队列中，RBP4水平与体重指数（BMI）、体脂、腰围、空腹血糖及葡萄糖曲线下面积均呈正相关（均P<0.05），但与胰岛素抵抗指标无关。另一方面，糖代谢受损的PCOS女性的RBP4水平高于糖代谢正常的PCOS女性（中位数30.6，范围23.3 - 73.9对中位数26.3，范围6.4 - 61.4，P<0.05）。此外，瘦型PCOS女性与BMI匹配的健康对照者的RBP4水平无差异。
在德国PCOS女性中，血清RBP4水平与肥胖及葡萄糖代谢参数相关，但与PCOS本身无关。
