Lingaiah Shilpa, Morin-Papunen Laure, Piltonen Terhi, Sundström-Poromaa Inger, Stener-Victorin Elisabet, Tapanainen Juha S
Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Endocr Connect. 2019 Jun 1;8(6):709-717. doi: 10.1530/EC-19-0116.
Serum levels of retinol-binding protein 4 (RBP4), an adipokine thought to affect systemic insulin sensitivity, were compared between women with polycystic ovary syndrome (PCOS) and non-PCOS controls to evaluate the association of RBP4 with clinical, hormonal and metabolic parameters of PCOS.
Serum RBP4 levels were analysed in 278 women with PCOS (age range 18-57 years) and 191 non-PCOS controls (age 20-53 years) by enzyme-linked immunosorbent assay.
Serum levels of RBP4 were increased in women with PCOS compared with control women in the whole population (45.1 ± 24.0 (s.d.) vs 33.5 ± 18.3 mg/L, P < 0.001). Age-stratified analysis showed that serum RBP4 levels were increased in women with PCOS aged ≤30 years compared with controls (47.7 ± 23.5 vs 27.1 ± 10.4 mg/L, P < 0.001), whereas no significant differences were seen in the other age groups. No significant correlations of RBP4 were seen with either steroids or indices of insulin resistance.
Although serum RBP4 levels were increased in younger women with PCOS compared with age-matched non-PCOS controls, RBP4 does not seem to be a good marker of insulin resistance or other metabolic derangements in women with PCOS.
比较多囊卵巢综合征（PCOS）女性与非PCOS对照者血清视黄醇结合蛋白4（RBP4，一种被认为会影响全身胰岛素敏感性的脂肪因子）水平，以评估RBP4与PCOS临床、激素及代谢参数之间的关联。
采用酶联免疫吸附测定法分析了278例PCOS女性（年龄范围18 - 57岁）和191例非PCOS对照者（年龄20 - 53岁）的血清RBP4水平。
在整个人群中，PCOS女性的血清RBP4水平高于对照女性（45.1±24.0（标准差）对33.5±18.3mg/L，P<0.001）。年龄分层分析显示，年龄≤30岁的PCOS女性血清RBP4水平高于对照者（47.7±23.5对27.1±10.4mg/L，P<0.001），而其他年龄组未见显著差异。RBP4与类固醇或胰岛素抵抗指标均无显著相关性。
尽管与年龄匹配的非PCOS对照者相比，年轻PCOS女性血清RBP4水平升高，但RBP4似乎并非PCOS女性胰岛素抵抗或其他代谢紊乱的良好标志物。
