Bratincsák András, Brownstein Michael J, Cassiani-Ingoni Riccardo, Pastorino Sandra, Szalayova Ildikó, Tóth Zsuzsanna E, Key Sharon, Németh Krisztián, Pickel James, Mezey Eva
National Institute of Mental Health, Bethesda, Maryland, USA.
Stem Cells. 2007 Nov;25(11):2820-6. doi: 10.1634/stemcells.2007-0301. Epub 2007 Jul 26.
The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus, but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we showed that CD45-positive hematopoietic progenitor cells colonize the uterine epithelium and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found green fluorescent protein (GFP)-positive uterine endothelial cells in long-term GFP bone marrow-transplanted mice, we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium.
子宫内膜由上皮细胞和基质细胞组成，这些细胞在每个发情周期都会经历广泛的退化和再生，并且在怀孕期间会发生显著变化。细胞的高更替率需要子宫中的祖细胞进行相应高水平的细胞分裂，但这些细胞的特征和来源仍不清楚。在本研究中，我们使用一种新型转基因小鼠，证明了CD45阳性造血祖细胞可定植于子宫上皮，并且在怀孕期间超过80%的上皮细胞可来源于这些细胞。由于我们还在长期接受绿色荧光蛋白（GFP）骨髓移植的小鼠中发现了GFP阳性的子宫内皮细胞，我们得出结论，循环中的CD45+细胞在子宫上皮再生中起重要作用。
