Zhang Zhi-Yong, Zhao Zeng-Ren, Adell Gunnar, Jarlsfelt Ingvar, Cui Yong-Xing, Kayed Hany, Kleeff Jorg, Wang Ming-Wei, Sun Xiao-Feng
Department of Oncology, Institute of Biomedicine and Surgery, Linkoping University, Linkoping, Sweden.
Oncology. 2006;71(3-4):259-65. doi: 10.1159/000106449. Epub 2007 Jul 26.
Meningioma-associated protein (MAC30) is overexpressed in several types of cancers, but its therapeutic implication in the patients has not been studied. We examined the relationship of MAC30 with clinicopathological and biological factors in rectal cancer patients with or without radiotherapy (RT).
MAC30 was immunohistochemically examined in 75 distant and 91 adjacent normal mucosa specimens, 132 primary tumours and 39 lymph node metastases from rectal cancer patients participating in a clinical trial of preoperative RT.
In the RT group, MAC30 was or tended to be positively correlated with infiltrated growth pattern (p = 0.02), PRL (phosphatase of regenerating liver, p = 0.01) and Ki-67 expression (p = 0.06). MAC30 at the invasive margin of the metastasis was related to poor survival (p = 0.02) in the whole group of patients. MAC30 in primary tumours was not related to recurrence and survival in the non-RT or RT group.
MAC30 expression in metastasis was an indicator for poor survival. After RT, MAC30 seemed to be more related to aggressive morphological and biological factors; however, we did not find direct evidence that MAC30 expression was related to the outcome of patients with or without RT.
脑膜瘤相关蛋白（MAC30）在多种癌症中过度表达，但尚未对其在患者中的治疗意义进行研究。我们研究了MAC30与接受或未接受放疗（RT）的直肠癌患者临床病理及生物学因素之间的关系。
对参与术前RT临床试验的直肠癌患者的75份远隔正常黏膜标本、91份相邻正常黏膜标本、132份原发性肿瘤标本及39份淋巴结转移标本进行MAC30免疫组织化学检测。
在RT组中，MAC30与浸润性生长模式（p = 0.02）、PRL（再生肝磷酸酶，p = 0.01）及Ki-67表达（p = 0.06）呈正相关或倾向于呈正相关。转移灶浸润边缘的MAC30与全组患者的不良生存相关（p = 0.02）。原发性肿瘤中的MAC30与非RT组或RT组的复发及生存无关。
转移灶中MAC30表达是不良生存的一个指标。放疗后，MAC30似乎与侵袭性形态学及生物学因素更相关；然而，我们未发现直接证据表明MAC
