铜与阿司匹林的协同作用提高了其抗炎活性。

Coordination of copper with aspirin improves its anti-inflammatory activity.

机构信息

Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, China.

出版信息

Inflammopharmacology. 1998;6(4):357-62. doi: 10.1007/s10787-998-0018-0.

Abstract

Anti-inflammatory activity of copper aspirinate administered orally was investigated in several models of inflammation. The results showed that copper aspirinate 50 mg/kg markedly inhibited inflammatory processes of either ear swelling induced by xylene in mice or turpentine-elicited air pouch granuloma in rats, with an activity equal to that of aspirin 200 mg/kg. Copper aspirinate 25 mg/kg significantly suppressed acute paw oedema produced by injecting 1% carrageenan, with an action time lasting over 6 h; and that copper aspirinate 100 mg/kg decreased the content of protein in the inflammatory exudate from rats with air pouch synovitis caused by acetic acid. It is suggested that, compared with aspirin, copper aspirinate showed a similar anti-inflammatory spectrum but greater anti-inflammatory activity.

摘要

研究了铜酞酸酯经口给药的抗炎活性，在几种炎症模型中进行了研究。结果表明，铜酞酸酯 50mg/kg 显著抑制了二甲苯诱导的小鼠耳肿胀或松节油诱导的大鼠气囊肉芽肿等炎症过程，其活性与阿司匹林 200mg/kg 相当。铜酞酸酯 25mg/kg 可显著抑制 1%角叉菜胶引起的急性足肿胀，作用时间超过 6 小时；而铜酞酸酯 100mg/kg 可降低醋酸引起的气囊滑膜炎大鼠炎症渗出物中蛋白质的含量。与阿司匹林相比，铜酞酸酯显示出相似的抗炎谱，但具有更强的抗炎活性。