阿司匹林铜和阿司匹林对佐剂性关节炎大鼠的抗炎活性
Antiinflammatory activities of copper-aspirinate and aspirin in adjuvant arthritic rats.
作者信息
Kishore V
机构信息
College of Pharmacy, Xavier University of Louisiana, New Orleans 70125.
出版信息
Res Commun Chem Pathol Pharmacol. 1988 May;60(2):257-60.
PMID:3393733
Abstract
The antiinflammatory activities of copper aspirinate and aspirin were determined in adjuvant arthritic rats following oral administration for twenty-one days. Results clearly indicated that copper aspirinate acts as a mixed agonist/antagonist showing agonist action at lower doses and antagonist action at higher doses.
摘要
在佐剂性关节炎大鼠中，连续21天口服给药后测定了阿司匹林铜和阿司匹林的抗炎活性。结果清楚地表明，阿司匹林铜作为一种混合激动剂/拮抗剂，在较低剂量时表现出激动剂作用，在较高剂量时表现出拮抗剂作用。
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