Holmes Katherine, Roberts Owain Ll, Thomas Angharad M, Cross Michael J
North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, University of Wales, Bangor, UK.
Cell Signal. 2007 Oct;19(10):2003-12. doi: 10.1016/j.cellsig.2007.05.013. Epub 2007 Jun 12.
Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.
血管内皮生长因子（VEGF）通过与多种受体结合来调节血管发育、血管生成和淋巴管生成。VEGFR-1是造血干细胞募集以及单核细胞和巨噬细胞迁移所必需的，VEGFR-2调节血管内皮功能，VEGFR-3调节淋巴管内皮细胞功能。在过去十年中，在描绘导致增殖、迁移、存活和通透性增加的VEGFR-2特异性细胞内信号级联反应方面取得了相当大的进展，其中每一种反应都有助于血管生成反应。此外，VEGFR-2作用的治疗性抑制目前正在临床上对多种疾病的治疗产生影响。
