Fujin Shengji Powder promotes healing of stage 3 pressure injury wounds in rats by modulating angiogenesis and inflammatory effects.

This study aimed to investigate the role of Fujin Shengji Powder (FJSJP) in promoting the healing of stage 3 pressure injury (PI) wounds and potential mechanisms. High-performance liquid chromatography was used to identify active components in FJSJP. A rat model of stage 3 PI wounds was induced via ischemia-reperfusion (I/R) injury. After successful modeling, rats in the control group received no treatment, while the positive group, negative group, and FJSJP group applied rb-bFGFG, vaseline, FJSJP to the wound, respectively, covering the wound by 2 mm continuously for 14 days. Results showed that the wound healing rate on days 3, 7, and 14 was higher in the FJSJP group than in the control groups, with complete re-epithelialization and evident regeneration of skin structures. Furthermore, FJSJP increased CD31 positive expression and elevated mRNA and protein levels of VEGF, VEGFR2, and ERK1/2 at the wound site. The anti-inflammatory effect was confirmed by reduced CD86 positive expression and downregulated TNF-α and IL-6. In summary, topical application of FJSJP can effectively treat stage 3 PI wounds in rats, providing new insights and evidence for its role in accelerating wound healing, promoting angiogenesis, and reducing inflammation.