Zeitoun Jean-David, Mallet Vincent, Chaix Marie-Laure, Viard Jean-Paul, Blanche Stéphane, Pol Stanislas
AP-HP, hôpital Cochin, hépatologie, Paris, France.
J Clin Virol. 2007 Sep;40(1):71-3. doi: 10.1016/j.jcv.2007.05.014. Epub 2007 Jul 19.
Co-infection by the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) is common. HIV co-infection worsens the course of HCV infection, particularly in patients with low CD4-cell count, enhancing the need to cancel HCV replication in HIV-infected patients. We report a case of spontaneous recovery of chronic HCV-infection in a HCV-HIV co-infected hemophiliac with the introduction of combined antiretroviral therapy and immune restoration. Retrospective analysis of frozen blood samples showed that a decrease in HCV-RNA in parallel with the increase of CD4 and CD8-cell counts, accompanied by a peak of transaminases. The respective effect of immune restoration and of high doses of ritonavir are discussed.
丙型肝炎病毒（HCV）与人类免疫缺陷病毒（HIV）合并感染很常见。HIV合并感染会使HCV感染病程恶化，尤其是在CD4细胞计数低的患者中，这增加了在HIV感染患者中消除HCV复制的必要性。我们报告了1例HCV-HIV合并感染的血友病患者在接受联合抗逆转录病毒治疗和免疫恢复后慢性HCV感染自发恢复的病例。对冷冻血样的回顾性分析显示，HCV-RNA水平下降，同时CD4和CD8细胞计数增加，并伴有转氨酶峰值。文中讨论了免疫恢复和高剂量利托那韦各自的作用。
