1,4-二羟基-2-萘甲酸[校正后]异戊烯基转移酶抑制剂的发现：针对多重耐药革兰氏阳性病原体的新型药物先导物
Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens.
作者信息
Kurosu Michio, Narayanasamy Prabagaran, Biswas Kallolmay, Dhiman Rakesh, Crick Dean C
机构信息
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523-1682, USA.
出版信息
J Med Chem. 2007 Aug 23;50(17):3973-5. doi: 10.1021/jm070638m. Epub 2007 Jul 21.
Abstract
Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as methicillin-resistant Stapylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-positive organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-positive organisms.
摘要
由于甲萘醌在电子传递系统中的利用是革兰氏阳性菌的一个特性，1,4 - 二羟基 - 2 - 萘甲酸异戊烯基转移酶（MenA）抑制剂1a和2a可作为针对耐甲氧西林金黄色葡萄球菌（MRSA）、表皮葡萄球菌（MRSE）和分枝杆菌属等细菌的选择性抗菌剂。耐药革兰氏阳性菌的生长对MenA抑制剂敏感，这表明甲萘醌合成是革兰氏阳性菌中一个有效的新药物靶点。
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