通过连续磁共振成像评估梭形颅内动脉瘤的生长情况。
Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging.
作者信息
Dispensa Bradley P, Saloner David A, Acevedo-Bolton Gabriel, Achrol Achal S, Jou Lianger-der, McCulloch Charles E, Johnston S Claiborne, Higashida Randall T, Dowd Christopher F, Halbach Van V, Ko Nerissa U, Lawton Michael T, Martin Alastair J, Quinnine Nancy, Young William L
机构信息
Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California-San Francisco, San Francisco, California 94110, USA.
出版信息
J Magn Reson Imaging. 2007 Jul;26(1):177-83. doi: 10.1002/jmri.20944.
PURPOSE
Intracranial aneurysm (IA) growth is associated with increased morbidity. We sought to establish a quantitative computational method based on contrast-enhanced MR angiography (CE-MRA) for estimating aneurysmal volume changes over time.
MATERIALS AND METHODS
Computational volume calculations were tested against a distensible phantom. Untreated patients with IA were followed longitudinally with annual MRI. Maximal linear dimensions along the longitudinal axis and two transverse axes were determined by visual review of maximum intensity projection (MIP) data, and aneurysm volume was approximated as (length x width x height)/2. Averages of the visual approximations were compared to the lumenal volume as determined with a computational algorithm using the MRI data.
RESULTS
MRI-based measurements accurately represented volume changes in the phantom (R2 = 0.97, Y = 1.06x + 271 CM3). In the clinical study there were a total of 11 intervals of one-year follow-up in six patients (mean +/- SD, age = 53 +/- 20 years). The raw one-year growth using the computational volume was 9% +/- 17%. The corresponding value for the averaged measurement of the reviewers was 8% +/- 14%. Neither the mean values nor the SDs were different (P = .51).
CONCLUSION
MRI-based measurement of aneurysm volume appears feasible for longitudinal studies of aneurysm natural history.
目的
颅内动脉瘤（IA）的生长与发病率增加相关。我们试图建立一种基于对比增强磁共振血管造影（CE-MRA）的定量计算方法，以估计动脉瘤体积随时间的变化。
材料与方法
针对可膨胀模型测试计算体积。对未经治疗的IA患者进行每年一次的MRI纵向随访。通过目视检查最大强度投影（MIP）数据确定沿纵轴和两个横轴的最大线性尺寸，动脉瘤体积近似为（长度×宽度×高度）/2。将目视近似值的平均值与使用MRI数据通过计算算法确定的管腔体积进行比较。
结果
基于MRI的测量准确反映了模型中的体积变化（R2 = 0.97，Y = 1.06x + 271 cm3）。在临床研究中，6例患者共有11个为期一年的随访间隔（平均±标准差，年龄 = 53±20岁）。使用计算体积得出的一年原始生长率为9%±17%。评审人员平均测量的相应值为8%±14%。平均值和标准差均无差异（P = 0.51）。
结论
基于MRI测量动脉瘤体积对于动脉瘤自然史的纵向研究似乎是可行的。
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