Bal Nebil, Yildirim Sedat, Nursal Tarik-Z, Bolat Filiz, Kayaselcuk Fazilet
Baskent University, Adana Research and Medical Center, Pathology Department, Yuregir, Adana 01250, Turkey.
World J Gastroenterol. 2007 Jul 21;13(27):3726-9. doi: 10.3748/wjg.v13.i27.3726.
To investigate the correlation between ezrin expression and types of gastric carcinoma and clinico-pathological variables.
We examined ezrin protein expression in 75 gastric carcinoma (53 intestinal types of adenocarcinoma, 22 diffuse types of carcinoma) tissues by immunohistochemistry. The results were compared with clinicopathological parameters such as tumor type, grade of tumor, clinical stage, presence of metastatic lymph node, and depth of invasion.
Ezrin immunostaining was positive in 43 cases (81.1%) of intestinal type and in 9 (40.9%) cases of diffuse type adenocarcinomas (P < 0.001). In gastric carcinomas, the expression of ezrin protein correlated with the status of H pylori and survival. There was no correlation between expression of ezrin with TNM stage and histological grade of gastric carcinomas (P > 0.05).
The low expression of ezrin implicates the loss of adhesion in diffuse carcinomas. Furthermore, overexpression of ezrin in carcinomas with H pylori infection may be a genuine specific pathway in which H pylori may cause/initiate gastric carcinoma.
探讨埃兹蛋白（ezrin）表达与胃癌类型及临床病理变量之间的相关性。
我们采用免疫组织化学方法检测了75例胃癌组织（53例肠型腺癌、22例弥漫型癌）中ezrin蛋白的表达情况。将结果与肿瘤类型、肿瘤分级、临床分期、有无转移淋巴结及浸润深度等临床病理参数进行比较。
埃兹蛋白免疫染色在43例（81.1%）肠型腺癌及9例（40.9%）弥漫型腺癌中呈阳性（P<0.001）。在胃癌中，埃兹蛋白的表达与幽门螺杆菌感染状况及生存率相关。埃兹蛋白的表达与胃癌的TNM分期及组织学分级之间无相关性（P>0.05）。
埃兹蛋白低表达提示弥漫型癌中黏附功能丧失。此外，幽门螺杆菌感染的癌组织中埃兹蛋白过表达可能是幽门螺杆菌引发胃癌的一条真正的特定途径。
