埃兹蛋白在伴有淋巴样间质和爱泼斯坦-巴尔病毒感染的胃癌中的表达及其磷酸化
Ezrin expression and its phosphorylation in gastric carcinoma with lymphoid stroma and Epstein-Barr virus infection.
作者信息
Tobo Taro, Hirahashi Minako, Yao Takashi, Aishima Shinichi, Oda Yoshinao
机构信息
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka;
Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Mol Clin Oncol. 2013 Mar;1(2):220-224. doi: 10.3892/mco.2012.56. Epub 2012 Dec 28.
Gastric carcinoma with lymphoid stroma (GCLS) is a unique variant of gastric carcinoma that represents prominent lymphocytic infiltration and is correlated with Epstein-Barr virus (EBV) infection. Ezrin expression and activation are crucial in tumor metastasis and induce cell migration of EBV-related nasopharyngeal carcinomas. Using immunohistochemical methods, the expression of total and phosphorylated ezrin (p-ezrin), Thr567, was examined in 104 GCLS cases, including 78 EBV-positive and 26 EBV-negative cases, as well as 29 non-GCLS cases. Positive ezrin expression was detected to be at markedly higher levels in GCLS compared to non-GCLS (P<0.0001). Furthermore, ezrin expression was detected to be at higher levels in EBV-positive compared to EBV-negative GCLS (P=0.0294). High expression of p-ezrin in GCLS was associated with positive lymph node metastasis (P=0.0187). In summary, these results demonstrated that ezrin overexpression is correlated with the histologic characteristics of GCLS and EBV infection. Phosphorylation of ezrin may, therefore, contribute to lymph node metastasis in GCLS.
伴有淋巴样间质的胃癌（GCLS）是胃癌的一种独特变体，其特征为显著的淋巴细胞浸润，且与爱泼斯坦-巴尔病毒（EBV）感染相关。埃兹蛋白（ezrin）的表达及激活在肿瘤转移中起关键作用，并可诱导EBV相关鼻咽癌的细胞迁移。采用免疫组化方法，检测了104例GCLS病例（包括78例EBV阳性和26例EBV阴性病例）以及29例非GCLS病例中总埃兹蛋白（ezrin）和磷酸化埃兹蛋白（p-ezrin，Thr567）的表达。结果发现，与非GCLS相比，GCLS中埃兹蛋白的阳性表达水平显著更高（P<0.0001）。此外，与EBV阴性的GCLS相比，EBV阳性的GCLS中埃兹蛋白表达水平更高（P=0.0294）。GCLS中p-ezrin的高表达与阳性淋巴结转移相关（P=0.0187）。总之，这些结果表明，埃兹蛋白过表达与GCLS的组织学特征及EBV感染相关。因此，埃兹蛋白的磷酸化可能在GCLS的淋巴结转移中发挥作用。
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