de Lemos Edite Teixeira, Reis Flávio, Baptista Sofia, Pinto Rui, Sepodes Bruno, Vala Helena, Rocha-Pereira Petronila, Silva Alice Santos, Teixeira Frederico
Therapeutics Unit, Institute of Pharmacology and Experimental Therapeutics, Medicine Faculty, Coimbra University, Coimbra, Portugal.
Med Sci Monit. 2007 Aug;13(8):BR168-74.
Chronic low-grade systemic inflammation is a feature of such chronic diseases as cardiovascular disease and type 2 diabetes (T2D). There is evidence that regular exercise is effective as a treatment in these situations. This study intended to assess the levels of two inflammatory mediators, C-reactive protein (CRP) and adiponectin, in Zucker Diabetic Fatty (ZDF, fa/fa) rats, an experimental model of T2D, and to determine whether exercise-induced changes in insulin resistance could be explained by modifications in these inflammation markers.
MATERIAL/METHODS: Male ZDF (Gmi fa/fa) rats and their littermates (Gmi +/+), aged 8 weeks, were randomly assigned in two groups: an exercise trained and a sedentary one. Swimming was conducted 1 h/day 3 days/week for 12 weeks. The rats were sacrificed 48 h after the last round of exercise. Rats had their body weight, insulin, adiponectin, CRP, as well as glucose, total cholesterol, triglycerides, MDA, and SOD measured and HOMA-IR calculated before and after the 12-week swimming training.
In the ZDF (fa/fa) rats underwent swimming exercise, all the metabolic abnormalities were totally or partially prevented (p<0.001), namely the hyperglycemic, hyperinsulinemic, and dyslipidemic pattern observed in their sedentary counterparts. Furthermore, even without body weight change, a plasma adiponectin increase (28.0%) and a CRP decrease (12.7%) were also observed.
A 12-week thrice-weekly swimming training was associated with improved measures of chronic inflammation markers as measured by adiponectin and CRP. Moreover, improvements in insulin sensitivity resulting from swimming exercise appeared to be related to changes in these inflammatory mediators.
慢性低度全身性炎症是心血管疾病和2型糖尿病（T2D）等慢性疾病的一个特征。有证据表明，规律运动在这些情况下作为一种治疗方法是有效的。本研究旨在评估2型糖尿病实验模型Zucker糖尿病脂肪大鼠（ZDF，fa/fa）中两种炎症介质C反应蛋白（CRP）和脂联素的水平，并确定运动引起的胰岛素抵抗变化是否可以通过这些炎症标志物的改变来解释。
材料/方法：8周龄的雄性ZDF（Gmi fa/fa）大鼠及其同窝出生的正常大鼠（Gmi +/+）被随机分为两组：运动训练组和久坐组。每周游泳3天，每天1小时，持续12周。在最后一轮运动后48小时处死大鼠。在12周游泳训练前后测量大鼠的体重、胰岛素、脂联素、CRP，以及血糖、总胆固醇、甘油三酯、丙二醛（MDA）和超氧化物歧化酶（SOD），并计算胰岛素抵抗稳态模型评估（HOMA-IR）。
在进行游泳运动的ZDF（fa/fa）大鼠中，所有代谢异常都得到了完全或部分预防（p<0.001），即久坐不动的同窝大鼠中观察到的高血糖、高胰岛素血症和血脂异常模式。此外，即使体重没有变化，血浆脂联素也增加了（28.0%），CRP降低了（12.7%）。
每周三次、为期12周的游泳训练与脂联素和CRP所测量的慢性炎症标志物指标改善有关。此外，游泳运动导致的胰岛素敏感性改善似乎与这些炎症介质的变化有关。
