Nishimura K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H
Department of Anesthesiology, School of Medicine, Juntendo University, Tokyo.
Masui. 1991 Nov;40(11):1686-90.
Kyotorphin is an analgesic neuropeptide isolated from the bovine brain in 1979. Further studies showed that kyotorphin produces an analgesia through an increased release of met-enkephalin in the brain and the spinal cord. We showed that it is also found in the human cerebrospinal fluid and the concentrations of kyotorphin in normal human CSF is 1.19 +/- 0.51 pmol.ml-1. We also found that it is lower in patients with persistent pain (0.24 +/- 0.04 pmol.ml-1). Above results suggest that kyotorphin acts as a putative neuromediator and/or an endogenous pain modulator in the human brain.
京都啡肽是1979年从牛脑中分离出的一种镇痛神经肽。进一步研究表明，京都啡肽通过增加脑和脊髓中甲硫氨酸脑啡肽的释放来产生镇痛作用。我们发现它也存在于人的脑脊液中，正常人脑脊液中京都啡肽的浓度为1.19±0.51 pmol·ml⁻¹。我们还发现，持续性疼痛患者的该浓度较低（0.24±0.04 pmol·ml⁻¹）。上述结果表明，京都啡肽在人脑中作为一种假定的神经介质和/或内源性疼痛调节剂发挥作用。
