• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synergistic effect of retinoic acid and 1,25-dihydroxyvitamin D3 on the differentiation of the human monocytic cell line U937.

作者信息

Taimi M, Chateau M T, Cabane S, Marti J

机构信息

INSERM U65, Département de Biologie-Santé, Université de Montpellier II, France.

出版信息

Leuk Res. 1991;15(12):1145-52. doi: 10.1016/0145-2126(91)90183-t.

DOI:10.1016/0145-2126(91)90183-t
PMID:1766263
Abstract

The human-derived leukemia cell lines HL-60 and U937 are known to differentiate into more mature phagocytic cells in the presence of retinoic acid or 1,25-dihydroxyvitamin D3. We studied the effects of combinations of these two agents on cell growth and differentiation. These treatments were found to increase inhibition of cell proliferation. A dramatic enhancement of functional properties was observed in U937, but not HL-60 cells exposed to combinations of the two inducers. We investigated the conditions required to obtain the highest synergistic effects on the differentiation of U937 cells. These effects were found to be highly dose-dependent. We found that synergism required the simultaneous presence of both inducers and did not occur upon sequential exposure to each agent used separately.

摘要

相似文献

1
Synergistic effect of retinoic acid and 1,25-dihydroxyvitamin D3 on the differentiation of the human monocytic cell line U937.
Leuk Res. 1991;15(12):1145-52. doi: 10.1016/0145-2126(91)90183-t.
2
Enhancement of activity of 1alpha, 25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin tocoferil, an alpha-tocopherol ester of all-trans retinoic acid.全反式维甲酸的α-生育酚酯维甲酸生育酚对1α,25-二羟基维生素D3活性的增强作用，以抑制人骨髓单核细胞白血病细胞生长并诱导其分化。
Blood. 1996 Apr 15;87(8):3384-94.
3
All-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes.全反式维甲酸与1α,25-二羟基维生素D3协同作用，促进人早幼粒细胞白血病细胞系HL60向单核细胞分化。
Leukemia. 1994 May;8(5):806-15.
4
M-CSF and 1,25 dihydroxy vitamin D3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells.巨噬细胞集落刺激因子（M-CSF）和1,25-二羟基维生素D3与12-O-十四烷酰佛波醇-13-乙酸酯协同作用，诱导急性早幼粒细胞白血病NB4细胞向巨噬细胞分化。
Leukemia. 1994 Oct;8(10):1744-9.
5
Synergistic differentiation of U937 cells by all-trans retinoic acid and 1 alpha, 25-dihydroxyvitamin D3 is associated with the expression of retinoid X receptor alpha.
Biochem Biophys Res Commun. 1994 Aug 30;203(1):272-80. doi: 10.1006/bbrc.1994.2178.
6
Particular combinations of signals, by retinoic acid and 1 alpha, 25 dihydroxyvitamin D3, promote apoptosis of HL60 cells.维甲酸和1α,25-二羟基维生素D3的特定信号组合可促进HL60细胞的凋亡。
Leukemia. 1995 Jul;9(7):1185-90.
7
Differentiation of U937 myelomonocytic cell line by all-trans retinoic acid and 1,25-dihydroxyvitamin D3: synergistic effects on tissue transglutaminase.全反式维甲酸和1,25-二羟基维生素D3对U937髓单核细胞系的分化作用：对组织转谷氨酰胺酶的协同效应
Leukemia. 1995 Oct;9(10):1762-7.
8
Treatment of HL60 cells with various combinations of retinoids and 1 alpha,25 dihydroxyvitamin D3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis.用视黄酸和1α,25-二羟基维生素D3的各种组合处理HL60细胞，会导致其向中性粒细胞或单核细胞分化，或者无法分化并发生凋亡。
Leukemia. 1995 Mar;9(3):410-8.
9
Thermal stress as an inducer of differentiation of U937 cells.
Leuk Res. 1993 Aug;17(8):649-56. doi: 10.1016/0145-2126(93)90069-w.
10
PML/RAR alpha+ U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3.PML/RARα+ U937突变体和NB4细胞系：维甲酸可恢复对维生素D3的单核细胞分化反应。
Cancer Res. 1994 Aug 15;54(16):4508-15.

引用本文的文献

1
Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.视黄酸受体α（RARα）和维生素D受体（VDR）共同占据的基因组区域参与了视黄酸和维生素D信号通路的汇聚与合作。
Nucleic Acids Res. 2025 Mar 20;53(6). doi: 10.1093/nar/gkaf230.
2
Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer.视黄醇 X 受体激动剂作为免疫系统的选择性调节剂用于癌症治疗。
Pharmacol Ther. 2023 Dec;252:108561. doi: 10.1016/j.pharmthera.2023.108561. Epub 2023 Nov 10.
3
Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.
维生素 D 状态有助于巨噬细胞对抗麻风分枝杆菌的抗菌活性。
PLoS Negl Trop Dis. 2018 Jul 2;12(7):e0006608. doi: 10.1371/journal.pntd.0006608. eCollection 2018 Jul.
4
Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3.通过视黄酸和1α,25 - 二羟基维生素D3联合处理诱导人髓系白血病细胞分化为M2巨噬细胞。
PLoS One. 2014 Nov 19;9(11):e113722. doi: 10.1371/journal.pone.0113722. eCollection 2014.
5
Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks.特定信号模块和相关转录因子网络对单核细胞分化的调控。
Cell Mol Life Sci. 2014 Jan;71(1):63-92. doi: 10.1007/s00018-013-1322-4. Epub 2013 Mar 24.
6
Bryostatin-1, Fenretinide and 1α,25 (OH)(2)D(3) Induce Growth Inhibition, Apoptosis and Differentiation in T and B Cell-Derived Acute Lymphoblastic Leukemia Cell Lines (CCRF-CEM and Nalm-6).苔藓抑素-1、维甲酸和1α,25（OH）₂D₃诱导T和B细胞来源的急性淋巴细胞白血病细胞系（CCRF-CEM和Nalm-6）生长抑制、凋亡和分化。
Avicenna J Med Biotechnol. 2011 Oct;3(4):177-93.
7
The human macrophage cell line U937 as an in vitro model for selective evaluation of mycobacterial antigen-specific cytotoxic T-cell function.人巨噬细胞系U937作为体外模型用于选择性评估分枝杆菌抗原特异性细胞毒性T细胞功能。
Immunology. 2001 Feb;102(2):146-56. doi: 10.1046/j.1365-2567.2001.01164.x.
8
Protective effect of thioredoxin upon NO-mediated cell injury in THP1 monocytic human cells.硫氧还蛋白对THP1人单核细胞中一氧化氮介导的细胞损伤的保护作用。
Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):759-65.
9
Prosomes (proteasomes) changes during differentiation are related to the type of inducer.前体（蛋白酶体）在分化过程中的变化与诱导剂的类型有关。
Mol Biol Rep. 1997 Mar;24(1-2):57-62. doi: 10.1023/a:1006856707793.
10
The retinoic acid analog CBS-211A potentiates the 1 alpha,25-dihydroxyvitamin D3-induced differentiation of U937 cells.维甲酸类似物CBS-211A可增强1α,25-二羟基维生素D3诱导的U937细胞分化。
Agents Actions. 1993 Jan;38(1-2):91-9. doi: 10.1007/BF02027219.