癌症与衰老中的细胞衰老

Cellular senescence in cancer and aging.

作者信息

Collado Manuel, Blasco Maria A, Serrano Manuel

机构信息

Spanish National Cancer Research Center (CNIO), Madrid, Spain.

出版信息

Cell. 2007 Jul 27;130(2):223-33. doi: 10.1016/j.cell.2007.07.003.

DOI:10.1016/j.cell.2007.07.003

PMID:17662938

Abstract

Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.

摘要

细胞衰老，即一种不可逆的生长停滞状态，可由多种机制引发，包括端粒缩短、INK4a/ARF 基因座的表观遗传去抑制以及 DNA 损伤。这些机制共同限制了细胞的过度或异常增殖，因此衰老状态可预防癌症的发生。最近的证据表明，细胞衰老也可能与衰老过程有关。