Jeyapalan Jessie C, Sedivy John M
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
Mech Ageing Dev. 2008 Jul-Aug;129(7-8):467-74. doi: 10.1016/j.mad.2008.04.001. Epub 2008 Apr 12.
Cellular senescence, first observed and defined using in vitro cell culture studies, is an irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging evidence suggests that cellular senescence acts as an in vivo tumor suppression mechanism by limiting aberrant proliferation. It has also been postulated that cellular senescence can occur independently of cancer and contribute to the physiological processes of normal organismal aging. Recent data have demonstrated the in vivo accumulation of senescent cells with advancing age. Some characteristics of senescent cells, such as the ability to modify their extracellular environment, could play a role in aging and age-related pathology. In this review, we examine current evidence that links cellular senescence and organismal aging.
细胞衰老最早是通过体外细胞培养研究观察和定义的，是一种不可逆的细胞周期停滞，可由多种因素触发。新出现的证据表明，细胞衰老通过限制异常增殖而作为一种体内肿瘤抑制机制。也有人推测，细胞衰老可以独立于癌症发生，并有助于正常机体衰老的生理过程。最近的数据表明，衰老细胞会随着年龄的增长在体内积累。衰老细胞的一些特征，如改变其细胞外环境的能力，可能在衰老和与年龄相关的病理过程中起作用。在这篇综述中，我们研究了将细胞衰老与机体衰老联系起来的当前证据。
