细胞衰老与机体衰老。
Cellular senescence and organismal aging.
作者信息
Jeyapalan Jessie C, Sedivy John M
机构信息
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
出版信息
Mech Ageing Dev. 2008 Jul-Aug;129(7-8):467-74. doi: 10.1016/j.mad.2008.04.001. Epub 2008 Apr 12.
Abstract
Cellular senescence, first observed and defined using in vitro cell culture studies, is an irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging evidence suggests that cellular senescence acts as an in vivo tumor suppression mechanism by limiting aberrant proliferation. It has also been postulated that cellular senescence can occur independently of cancer and contribute to the physiological processes of normal organismal aging. Recent data have demonstrated the in vivo accumulation of senescent cells with advancing age. Some characteristics of senescent cells, such as the ability to modify their extracellular environment, could play a role in aging and age-related pathology. In this review, we examine current evidence that links cellular senescence and organismal aging.
摘要
细胞衰老最早是通过体外细胞培养研究观察和定义的，是一种不可逆的细胞周期停滞，可由多种因素触发。新出现的证据表明，细胞衰老通过限制异常增殖而作为一种体内肿瘤抑制机制。也有人推测，细胞衰老可以独立于癌症发生，并有助于正常机体衰老的生理过程。最近的数据表明，衰老细胞会随着年龄的增长在体内积累。衰老细胞的一些特征，如改变其细胞外环境的能力，可能在衰老和与年龄相关的病理过程中起作用。在这篇综述中，我们研究了将细胞衰老与机体衰老联系起来的当前证据。
相似文献
1
Cellular senescence and organismal aging.细胞衰老与机体衰老。
Mech Ageing Dev. 2008 Jul-Aug;129(7-8):467-74. doi: 10.1016/j.mad.2008.04.001. Epub 2008 Apr 12.
2
Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells.糖尿病中的细胞衰老：脂肪组织和胰腺 β 细胞的独特衰老治疗策略。
Front Endocrinol (Lausanne). 2022 Mar 31;13:869414. doi: 10.3389/fendo.2022.869414. eCollection 2022.
3
Cellular senescence in cancer and aging.癌症与衰老中的细胞衰老
Cell. 2007 Jul 27;130(2):223-33. doi: 10.1016/j.cell.2007.07.003.
4
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.细胞周期蛋白依赖性激酶抑制剂p21和p16在人成纤维细胞衰老和分化机制中的不同作用。
Mol Cell Biol. 1999 Mar;19(3):2109-17. doi: 10.1128/MCB.19.3.2109.
5
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression.p16INK4a-RB 通路：细胞衰老与肿瘤抑制之间的分子联系。
J Med Invest. 2004 Aug;51(3-4):146-53. doi: 10.2152/jmi.51.146.
6
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.肿瘤抑制因子和衰老生物标志物 p16(INK4a) 在没有相关炎症分泌表型的情况下诱导细胞衰老。
J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.
7
The role of p21 in cellular senescence and aging-related diseases.p21 在细胞衰老和与衰老相关疾病中的作用。
Mol Cells. 2024 Nov;47(11):100113. doi: 10.1016/j.mocell.2024.100113. Epub 2024 Sep 19.
8
Senescence research from historical theory to future clinical application.衰老研究：从历史理论到未来临床应用。
Geriatr Gerontol Int. 2021 Feb;21(2):125-130. doi: 10.1111/ggi.14121. Epub 2020 Dec 28.
9
The role of chromatin reorganization in the process of cellular senescence.染色质重构在细胞衰老过程中的作用。
Curr Drug Targets. 2012 Dec;13(13):1593-602. doi: 10.2174/138945012803529983.
10
Regulation of growth arrest in senescence: telomere damage is not the end of the story.衰老过程中生长停滞的调控：端粒损伤并非故事的全部。
Mech Ageing Dev. 2006 Jan;127(1):16-24. doi: 10.1016/j.mad.2005.09.002. Epub 2005 Oct 17.
引用本文的文献
1
The age-associated decline in neuroplasticity and its implications for post-stroke recovery in animal models of cerebral ischemia: The therapeutic role of extracellular vesicles.与年龄相关的神经可塑性下降及其对脑缺血动物模型中风后恢复的影响：细胞外囊泡的治疗作用。
J Cereb Blood Flow Metab. 2025 Aug 6:271678X251365020. doi: 10.1177/0271678X251365020.
2
Cellular senescence-from solid organs to vascularized composite allotransplants.细胞衰老——从实体器官到血管化复合异体移植
Geroscience. 2025 Jul 28. doi: 10.1007/s11357-025-01788-2.
3
Ligand-specific regulation of a binary enhancer code dictating cellular senescence.决定细胞衰老的二元增强子编码的配体特异性调控。
Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2506321122. doi: 10.1073/pnas.2506321122. Epub 2025 Jun 10.
4
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy.BCL2家族：从细胞凋亡机制到靶向治疗的新进展
Signal Transduct Target Ther. 2025 Mar 21;10(1):91. doi: 10.1038/s41392-025-02176-0.
5
Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events.身体成分与衰老：多酚对与衰老相关事件的影响。
Nutrients. 2024 Oct 25;16(21):3621. doi: 10.3390/nu16213621.
6
Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells.研究白屈菜酸对氧化应激诱导的人皮肤成纤维细胞过早细胞衰老的影响。
Life (Basel). 2024 Aug 27;14(9):1070. doi: 10.3390/life14091070.
7
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.METTL3 介导的染色质接触通过衰老过程中的代谢重编程促进应激颗粒的液-液相分离。
Nat Commun. 2024 Jun 26;15(1):5410. doi: 10.1038/s41467-024-49745-5.
8
Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion.衰老细胞在肾上腺中的积累通过分泌白细胞介素 1β诱导皮质酮的过度分泌。
Aging Cell. 2024 Sep;23(9):e14206. doi: 10.1111/acel.14206. Epub 2024 May 20.
9
Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds.细胞衰老程序对聚合组织支架中的物理差异敏感。
ACS Mater Au. 2023 Oct 6;4(1):35-44. doi: 10.1021/acsmaterialsau.3c00057. eCollection 2024 Jan 10.
10
Carnitine acetyltransferase deficiency mediates mitochondrial dysfunction-induced cellular senescence in dermal fibroblasts.肉碱乙酰转移酶缺陷介导皮肤成纤维细胞线粒体功能障碍诱导的细胞衰老。
Aging Cell. 2023 Nov;22(11):e14000. doi: 10.1111/acel.14000. Epub 2023 Oct 13.
本文引用的文献
1
Delayed kinetics of DNA double-strand break processing in normal and pathological aging.正常衰老和病理性衰老过程中DNA双链断裂修复的延迟动力学
Aging Cell. 2008 Jan;7(1):89-100. doi: 10.1111/j.1474-9726.2007.00354.x. Epub 2007 Dec 19.
2
Role of telomeres in vascular senescence.端粒在血管衰老中的作用。
Front Biosci. 2008 Jan 1;13:2971-9. doi: 10.2741/2902.
3
Studying telomeres in a longitudinal population based study.在一项基于纵向人群的研究中对端粒进行研究。
Front Biosci. 2008 Jan 1;13:2960-70. doi: 10.2741/2901.
4
Aging, graying and loss of melanocyte stem cells.黑素细胞干细胞的衰老、白化及丧失。
Stem Cell Rev. 2007 Fall;3(3):212-7. doi: 10.1007/s12015-007-0028-0.
5
Leukocytes of exceptionally old persons display ultra-short telomeres.高龄老人的白细胞表现出超短的端粒。
Am J Physiol Regul Integr Comp Physiol. 2007 Dec;293(6):R2210-7. doi: 10.1152/ajpregu.00615.2007. Epub 2007 Sep 26.
6
Telomere length, stem cells and aging.端粒长度、干细胞与衰老。
Nat Chem Biol. 2007 Oct;3(10):640-9. doi: 10.1038/nchembio.2007.38.
7
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.在过表达突变型和野生型核纤层蛋白A的人成纤维细胞中，端粒加速缩短和复制性衰老。
Exp Cell Res. 2008 Jan 1;314(1):82-91. doi: 10.1016/j.yexcr.2007.08.004. Epub 2007 Aug 16.
8
Premature senescence of mesothelial cells is associated with non-telomeric DNA damage.间皮细胞的过早衰老与非端粒DNA损伤有关。
Biochem Biophys Res Commun. 2007 Oct 26;362(3):707-11. doi: 10.1016/j.bbrc.2007.08.047. Epub 2007 Aug 20.
9
Cellular senescence: when bad things happen to good cells.细胞衰老：当好事发生在好细胞上时。 （注：原英文表述似乎不太符合正常逻辑，正常应该是不好的事情发生在细胞上才会导致衰老，这里按照字面意思翻译）
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40. doi: 10.1038/nrm2233.
10
Cellular senescence in cancer and aging.癌症与衰老中的细胞衰老
Cell. 2007 Jul 27;130(2):223-33. doi: 10.1016/j.cell.2007.07.003.
Zotero 插件