Böhmer A
Department of Otolaryngology, University Hospital, Zürich, Switzerland.
Laryngoscope. 1991 Dec;101(12 Pt 1):1307-12. doi: 10.1002/lary.5541011209.
The mechanism leading to hearing impairment in perilymph fistulas was investigated in guinea pigs with perforated round window membranes (RWM) by analyzing alterations of inner ear fluid pressure, changes of auditory function following manipulations to get presumed air bubbles out of the cochlea ("positional audiometry"), and temporal bone sections. The instantaneous loss of normal positive inner ear fluid pressure after RWM perforation had no immediate effect on auditory function. Inner ear pressure was restored 4 days following RWM perforation. "Positional audiometry" was negative in guinea pigs with perforated RWM. All ears in which auditory thresholds had increased had additional iatrogenic lesions at the spiral lamina. Fistulas in the RWM per se do not affect auditory thresholds. The question of the surgical repair of fistulas was not directly addressed; it only can be concluded that there are no direct sequelae of an isolated fistula which induce auditory impairment and which could be prevented by surgical repair of the fistula.
通过分析内耳液压变化、为排出耳蜗内假定气泡而进行操作后听觉功能的改变（“体位性听力测定”）以及颞骨切片，研究了豚鼠圆窗膜（RWM）穿孔导致听力损害的机制。RWM穿孔后正常内耳正液压的瞬间丧失对听觉功能无直接影响。RWM穿孔4天后内耳压力恢复。RWM穿孔的豚鼠“体位性听力测定”结果为阴性。所有听觉阈值升高的耳朵在螺旋板处均有额外的医源性损伤。RWM本身的瘘管并不影响听觉阈值。未直接探讨瘘管手术修复的问题；仅可得出结论，孤立瘘管不存在导致听觉损害且可通过瘘管手术修复预防的直接后遗症。
