Kaseki Y, Nakashima T, Fukuta S, Suzuki T, Yanagita N
Department of Otorhinolaryngology, Nagoya University School of Medicine, Japan.
Laryngoscope. 1991 Oct;101(10):1085-90. doi: 10.1288/00005537-199110000-00010.
To study the effects of a persistent perilymph fistula on the cochlea, a small cannula was inserted into the scala tympani of the basal turn of cochlea in guinea pigs. A month later, cochlear morphology and blood flow were studied using either histological evaluation or the microsphere surface preparation technique. Some animals showed no cochlear morphologic changes or no cochlear blood-flow reduction, even if tubal patency was maintained and perilymph leakage lasted for 1 month. This suggests that a prolonged perilymph fistula, per se, causes no permanent cochlear damage. However, in some animals, hair cell damage and cochlear blood-flow disorders were observed. These observations and the causes of hearing loss in clinical cases of perilymph fistula were studied.
为研究持续性外淋巴瘘对耳蜗的影响，将一根小插管插入豚鼠耳蜗底转鼓阶。一个月后，采用组织学评估或微球表面制备技术研究耳蜗形态和血流情况。即使维持咽鼓管通畅且外淋巴漏持续1个月，一些动物仍未出现耳蜗形态学改变或耳蜗血流减少。这表明，长时间的外淋巴瘘本身不会造成永久性耳蜗损伤。然而，在一些动物中，观察到了毛细胞损伤和耳蜗血流紊乱。对这些观察结果以及外淋巴瘘临床病例中听力损失的原因进行了研究。
