Clements K M, Wainwright P E
Department of Psychology, University of Waterloo, Waterloo, Ont., N2L 3G1 Canada.
Behav Brain Res. 2007 Nov 2;183(2):169-77. doi: 10.1016/j.bbr.2007.06.008. Epub 2007 Jun 20.
This is the second in a series of studies that uses various configurations of the water radial arm to characterize the mnemonic systems in the spontaneously hypertensive rat (SHR) which is used frequently as a rodent model of attention deficit hyperactivity disorder. The first study indicated that SHR were impaired on a win-shift version of the task that required the use of spatial extra-maze cues to locate the hidden platform. The objective of the present study was to assess the performance of male SHR, Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats on (i) a win-stay version of the task that requires the use of proximal cue-based visual discrimination, and (ii) a conditioned cue preference task that is considered a measure of affective conditioning. In the win-stay task, SHR made fewer total errors than WKY and SD at the beginning of testing and after reversal of the value of the cues. In the conditioned cue preference task, SHR spent a similar amount of time in both arms; whereas, SD and WKY spent significantly more time in the arm with the cue that was associated with the platform. These findings indicate that SHR are not impaired on either the acquisition or reversal of a cued visual discrimination task in the radial water maze, but are impaired in terms of their performance on an affective learning task.
这是一系列研究中的第二篇，该系列研究使用水迷宫的各种配置来表征自发性高血压大鼠（SHR）的记忆系统，SHR常被用作注意力缺陷多动障碍的啮齿动物模型。第一项研究表明，在需要使用空间迷宫外线索来定位隐藏平台的任务的赢-转换版本中，SHR表现受损。本研究的目的是评估雄性SHR、Wistar-Kyoto（WKY）和Sprague-Dawley（SD）大鼠在以下任务中的表现：（i）需要使用基于近端线索的视觉辨别力的任务的赢-保持版本，以及（ii）被认为是情感条件化测量指标的条件线索偏好任务。在赢-保持任务中，在测试开始时以及线索值反转后，SHR的总错误数比WKY和SD少。在条件线索偏好任务中，SHR在双臂中花费的时间相似；而SD和WKY在与平台相关的线索所在的臂中花费的时间明显更多。这些发现表明，SHR在放射状水迷宫中线索视觉辨别任务的习得或反转方面没有受损，但在情感学习任务的表现方面受损。
